Clots that develop in the deep veins of the legs or the lungs can result in pain, heart and
lung disease and may lead to death if unrecognized or not treated. Risk factors for
developing clots include surgery, hospitalization and/or being immobile. Up to 10 to 40% of
people may develop a clot during or after their hospital stay or surgery, and sometimes
these clots do not cause symptoms. In order to help reduce the risk of developing a clot in
the legs or ... Read More
This study is designed to compare the incidence of delayed graft function in patients
following renal transplant surgery with different perioperative hemodynamic managements: a
goal directed hemodynamic management group (using PiCCO) and a control group.
The purpose of this study is to test a tablet-based application called VIP Transplant,
devised to improve the recovery experience of patients that have recently had organ
transplant surgery. The study will consist of two non-randomized arms: the first arm will
consist of usual care and the second will be using the newly developed app for 21 days to
replace their in-person visits. Using questionnaires and in-app usage metrics, the research
team will track ... Read More
Source: National Institute of Allergy and Infectious Diseases (NIAID)
During transplant surgery, there is a period of time when a donated kidney is removed from a
donor's body and stored until the time of the transplant surgery. The storage procedure
results in buildup of various proteins within the kidney that can injure the donated kidney
after it is transplanted. One of these proteins is tumor necrosis factor-alpha (TNF-alpha).
The purpose of this study is to evaluate whether taking infliximab, which blocks TNF-alpha,
just ... Read More
This is a randomized controlled trial to assess ways to address post-operative ileus (POI)
in adult patients on the liver transplant service undergoing either liver transplant or
resection surgery. Patient who speak and understand English will be randomized into one of
three groups including a.)control group receiving standard therapy for post-operative ileus,
b.)group receiving standard therapy and acupressure bracelets, and c.)group receiving
standard ... Read More
This study is being done to collect blood and bone marrow samples for biologic studies of
antibody producing cells. Donor specific antibodies can cause damage to the kidneys after
they are transplanted. The study will look at the impact of immunosuppression on antibody
production by antibody producing cells.
This study will test the safety and tolerability of HCV Entry Inhibitor ITX 5061 in Liver
Transplant Recipients with Hepatitis C infection. The investigators hypothesize that ITX
5061 oral monotherapy will be safe in adults during and after liver transplantation and that
therapy will also inhibit HCV infection of newly transplanted livers in adults with prior
Graft rejection has traditionally been one of the leading causes of cornea transplant
failure. To help prevent rejection, corticosteroid eye drops are used for an extended period
after transplant surgery. The purpose of this study is to compare the efficacy and side
effects of different corticosteroid dosing regimens after endothelial keratoplasty (cornea
The purpose of this study is to assess the efficacy and safety of the study drug, known as
"ATG Fresenius S," which is sometimes called "EZ-2053," to prevent a lung transplant
patient's body from rejecting a transplanted lung or lungs.
This clinical trial studies fluorine F 18 L-glutamate derivative BAY94-9392 (18F-FSPG)
positron emission tomography (PET) in imaging patients with liver cancer before undergoing
surgery or transplant. Diagnostic procedures, such as 18F-FSPG PET, may help find and
diagnose liver cancer and find out how far the disease has spread.
Primary graft dysfunction (PGD) is a severe lung complication that can occur in the days
after lung transplant surgery. This study will analyze blood samples to determine if high
levels of certain chemicals may increase the risk of developing PGD after a lung transplant.
Abdominal wall transplantation surgery is the transfer of abdominal wall tissues from a
deceased human donor to a patient with a large abdominal wall defect. Abdominal wall
transplantation is an innovative reconstructive procedure that has the potential to
significantly improve the lives of patients with large abdominal wall defects. The purpose
of this study is to develop the best practices for abdominal wall transplantation that will
improve the outcomes ... Read More
The surgeon places the catheter in the thickness of the oblique internal and transverse
muscles at the moment the wall is closed, under visual control. A multiperforated catheter
whose length corresponds to that of the incision is chosed. The catheter will deliver one of
two products chosen at random: either ropivacaine or placebo.
This study will evaluate postoperative pain during the first 24 hours thanks to a recognized
indicator the VAS (Visual Analogue ... Read More
The purpose of this study is to compare two different commonly used steroid dosing regimens
after Descemet's membrane endothelial keratoplasty (DMEK) transplant surgery. The
investigators hope to determine if one is more effective at preventing rejection or if both
are equally effective.
Kidney transplantation is the best treatment for many patients with kidney failure.
Sometimes a transplanted kidney is rejected by the patient's immune system. Many types of
immune system cells, including B cells, are active in rejection. B cells produce antibodies
against anything the body sees as non-self, like germs or a transplanted kidney. Most
medicines that help prevent transplant rejection affect cells other than B cells. Belimumab
is a medication ... Read More
The hypothesis of this study is that subtotal parathyroidectomy using minimally invasive
surgery is superior to cinacalcet for the treatment of persistent secondary
hyperparathyroidism (HPT) post renal transplant, with minimal morbidity and significantly
reduces the cost of treatment post transplant.
The purpose of the study is to compare ultrasound measurements of the liver obtained prior
to surgery on the skin to measurements obtained during surgery directly on the diseased
liver. The objective is to determine if ultrasounds of the liver on the skin can provide
accurate measurements of disease of the liver to provide an alternative option to liver
Primary graft dysfunction (PGD) is a severe lung injury that can occur in the days following
lung transplant surgery. The purpose of this study is to identify genetic factors that may
put someone at risk for developing PGD.