Tranexamic acid(TXA) is an antifibrinolytic agent to reduce blood loss in cardiac surgery.
Previous seven RCTs comparing effects of TXA in pediatric cardiac surgery showed conflict
results. The reason why they showed mixed results would be the imbalance of patients
population with regard to presence of cyanosis. TXA would reduce blood loss in pediatric
cardiac surgery with well balanced patients population.
The purpose of this study is to investigate the safety, tolerability and efficacy of
octaplas in pediatric patients who require replacement of multiple coagulation factors.
Replacement of multiple coagulation factors in pediatric patients with acquired deficiencies
due to liver disease and in pediatric patients requiring cardiac surgery or liver surgery.
The purpose of this study is to determine if intraocular infusion of low-molecular weight
heparin (enoxaparin) influences postoperative inflammation following pediatric cataract
surgery with intraocular lens (IOL) implantation.
Cataract surgery is known to cause loss of corneal endothelial cells. In adults, it is
reported that anywhere between 2 to 15% loss of corneal endothelial cell density occurs
following cataract surgery. However, no data is available regarding endothelial changes
after cataract surgery with IOL implantation in pediatric eyes.
The aim of this study is to prospectively observe changes in endothelial cell density,
coefficient of variation and hexagonality ... Read More
Source: Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle
Long surgical wait-times and limited hospital capacity are common obstacles to surgical care
in many countries in sub-Saharan Africa (SSA). Ambulatory surgery might offer a solution to
these problems. The aim is to study the introduction of ambulatory surgery in a pediatric
hospital in SSA.
This is a cross-sectional descriptive study which took place over 6 months. It includes all
the patients assigned to ambulatory surgery in the Pediatric University ... Read More
The objective of the study is to assess the safety and efficacy of two doses of IV
palonosetron each administered as a single dose for the prevention of postoperative nausea
and vomiting through 72 hours postoperatively in children aged 28 days up to 16 years
inclusive undergoing surgical procedures requiring general endotracheal inhalation
Acute appendicitis is the most common illness that brings pediatric patients to the hospital
for surgical treatment. Abdominal pain is the symptom because of which the patients go to
the hospital. Some patients have severe pain and need analgesics before the final diagnosis
and before surgery. After surgery most patient experience pain and at least 80 % of the
patients need postoperative pain medication. For two decades there has been a clinical
guideline ... Read More
Directly following cardiac surgery for congenital heart disease; patients are not receiving
routine turning every two hours to prevent pressure ulcers, because a negative influence on
hemodynamic parameters is assumed. Investigators have suggested that lateral position may
have clinically significant effects on oxygenation in cardiac surgery patients.
The purpose of this study is to determine how Bispectral index (BIS) and Entropy EEG
monitors agree between themselves and with end-tidal concentration of sevoflurane (ETsevo)
in relationship with the age in the pediatric surgery setting.
Bispectral index (BIS) and Entropy EEG monitors performance and utility is well established
in adult general anesthesia.
Their utility is yet undefined in the pediatric population as age seems to affect their
... Read More
The investigators primary objective is to determine if acute normovolemic hemodilution (ANH)
for pediatric cardiac surgical patients decreases the volume of blood products transfused
during surgery and the immediate post-operative period as compared to usual care. This study
will enroll 24 pediatric heart surgery patients, aged 6 months to 3 years old undergoing
either ANH prior to initiating cardiopulmonary bypass or the standard of care procedures for
the ... Read More
The purpose of this study is to compare anti-inflammatory effects of two anti-fibrinolyntic
drugs (Tranexamic acid versus Epsilon-aminocaproic acid) in pediatric patients undergoing
pediatric cardiac surgery.
The purpose of this study is to describe the pharmacokinetics of AL-60371 otic suspension
following two posologies of bilateral ototopical doses in pediatric subjects immediately
after bilateral tympanostomy tube surgery.
In this study, the investigators hypothesized that perioperative i.v. infusion of lidocaine
in major abdominal pediatric surgery, may have a beneficial effect on hemodynamic and
hormonal responses. Also, it could decrease the hospital stay, opioid requirement and hasten
return of bowel function.