The Departments of Neurology and Neurosurgery are conducting this research study to evaluate
the safety and effectiveness of intravascular angioplasty for the treatment of venous
narrowing in the treatment of Multiple Sclerosis (MS).
Standard treatment of glioblastomas (GBMs) consists of microsurgical resection followed by
concomitant chemoradiation. The extent of resection is one of the most important prognostic
factors with significant influence on the survival of patients. State of the art technique
to achieve the most radical resection possible in conventional surgery is
fluorescence-guidance with 5-aminolevulinic acid (5-ALA). If available, intraoperative MRI
(iMRI)-guided tumor ... Read More
Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce
neural damage during neurosurgery.
As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial
NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is
preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in
clinical use. But there have been no reports about the effect of ... Read More
The purpose of this study is to collect data regarding the safety and feasibility of the
GO-LIF procedure for spinal fixation and stabilization, in conjunction with conventional
approaches for interbody lumbar fusion. This is in order to allow for evidence-based
comparison to pedicle-screw-based techniques as described in the literature.
Since neurological testing during neurosurgery, such as somato-sensory evoked potentials,
motor-evoked potentials, auditory evoked potentials and visual evoked potentials are well
maintained their wave-form reactivity with total intravenous anaesthesia technique better
than inhalational anesthetic techniques, the standard anesthesia method for neurosurgery is
usually total intravenous anaesthesia technique. Nonetheless, after finishing recording the
evoked ... Read More
Failure of ventricular catheters remains a significant problem in patients with
hydrocephalus. The purpose of this study is to determine whether the use of a simple
instrument assisted by a smart phone application software can achieve a more precise
placement of ventricular catheters than the standard free-hand placement technique.
Source: China International Neuroscience Institution
record,describe and discuss the relationship among rSO2, MAP,CAM value, vital organ
disfunction and the outcome of patients after operation by Near-Infrared Spectroscopy in
In this multinational dose finding Phase IIb study the efficacy and safety of two doses of
AP 12009 compared to standard chemotherapy (temozolomide or PCV) is investigated in adult
patients with confirmed recurrent high-grade glioma.
54 patients with idiopathic Parkinson's disease and freezing of gait resistant to
subthalamic nucleus stimulation and dopaminergic medication will be included into this
multicentre randomised controlled double-blinded parallel group clinical trial. The
treatment consists of two different stimulation settings using (i) conventional stimulation
of the subthalamic nucleus [standard STN] as active comparator and (ii) combined stimulation
of active electrode ... Read More
In this study the investigators will use semi-structured interviews to qualitatively analyse
patient and family member experiences with either deep brain stimulation or other forms of
The purpose of this clinical investigation is to evaluate the safety and effectiveness of
the ACD in the single level surgical treatment of patients with symptomatic cervical
degenerative disc disease. The primary follow-up information obtained from this clinical
investigation are used to support a PMA application for the ACD.
The prognosis of patients with newly diagnosed glioblastoma is dismal despite recent
therapeutic improvements Using standard therapy with temozolomide (TMZ) and radiotherapy (60
Gy), the median overall survival time (mOS) is 14.6 months (Stupp et al., 2005). Since in a
previous non-randomized bicentric phase II trial, primary combination chemotherapy with
lomustine (CCNU) and TMZ was highly effective (mOS 23 months; UKT-03 trial; Herrlinger et
al., 2006; ... Read More
The purpose of this study is to explore the effectiveness of lung-protective ventilation
during general anesthesia for neurosurgical procedures on postoperative pulmonary outcome,
compared with traditional ventilation.
The aim of this study is to asses the efficacy and the clinical safety of the transcranial
magnetic resonance guided high intensity focused ultrasound system ExAblate 4000, InSightec
Ltd. for functional neurosurgery. The treatments to be conducted in this study are
non-invasive, i.e. without opening the skull, and will create micro-thalamotomies in
specific target areas such as thalamus, subthalamus and pallidum. The data obtained in this
study will be used ... Read More
The study will be a multicenter randomised controlled trial of the use of irrigation fluid
of body temperature versus irrigation fluid of room temperature during burr hole evacuation
of chronic subdural hematoma.