This multicenter, open-label extension study of Protocol 2993-112 is designed to assess
long-term glucose control as measured by HbA1c (glycosylated hemoglobin) and to evaluate
long-term safety and tolerability in subjects treated with metformin who receive
subcutaneously injected AC2993 (10 mcg) administered twice daily. Subjects completing
Protocol 2993-112 are eligible to enroll.
To answer the question of overall benefit: risk of celecoxib when compared to two most
commonly prescribe traditional (non-selective) nonsteroidal anti-inflammatory drugs (NSAIDs)
in the treatment of arthritis pain. For this purpose, patients with osteoarthritis or
rheumatoid arthritis with or at risk of developing cardiovascular disease will be recruited.
The cardiovascular, gastrointestinal and renal safety and symptomatic benefit in each
treatment group ... Read More
A4091064 is a multicenter, long-term observational study of subjects from tanezumab
interventional studies (regardless of treatment group) who undergo a total knee, hip or
shoulder replacement during participation in the study. The study is designed with a total
duration of subject follow-up of 24 weeks after the total joint replacement surgery. There
will be two methods of data collection utilized in this study: interview by site staff via
the telephone and ... Read More
Evaluate effects of an oral nutritional supplement on healthcare outcomes in older
hospitalized adults. Also referred to as the NOURISH Study - Nutrition effect On Unplanned
Readmissions and Survival in Hospitalized patients.
The purpose of this study is to compare the long-term joint safety and efficacy (pain
relief) of the investigational study drug, tanezumab compared to non-steroidal anti
inflammatory drugs (NSAIDs) in subjects with osteoarthritis of the hips or knees.
Overactive bladder (OAB) is a syndrome characterized by symptoms of a sudden need to urinate
with or without incontinence (leaking). The purpose of this study is to test whether
dexmecamylamine is safe and effective compared to placebo for the treatment of symptoms of
The purpose of the research study is to find out if opioid dependent chronic pain patients
who are judged by their physician to be eligible to change their current opioid medicine and
to participate in this study can be successfully adjusted to a stable dose of EMBEDA
(morphine sulfate and naltrexone hydrochloride). The study will also assess each patient's
risk for prescription opioid abuse, misuse and diversion.
The main purpose of the trial is to evaluate pulmonary function in subjects who had
completed any one of the 4 MKC parent trials (MKC-TI-009, MKC-TI-102, MKC-TI-103, or
MKC-TI-030) for an additional 2-month safety follow-up.
This study is a multicenter, randomized study in subjects with high cholesterol receiving
highly effective statins to assess the efficacy, safety and tolerability of Bococizumab
(PF-04950615;RN316) to lower LDL-C.
This study will evaluate the efficacy, safety, and tolerability of selonsertib (formerly
GS-4997) in participants with diabetic kidney disease (DKD). Participants will be randomized
with a 1:1:1:1 allocation to receive 1 of 3 doses of selonsertib (2 mg, 6 mg, or 18 mg) or