Source: Norwegian University of Science and Technology
The purpose of this study is to compare and evaluate the diagnostic performance of scrape
cytology using two different cytological staining techniques, and to evaluate additional
touch imprint cytology with that of histopathology of superficial basal cell carcinoma and
150 patients who had suspected pancreatic malignancy were planed to be enrolled in this
study. Equal cytological samples of each patient undergoing EUS-FNA were examined by digital
image analysis and conventional cytology respectively. The investigators aim to compare the
efficacy of DIA and conventional cytology in diagnosing pancreatic cancer. Further more, the
investigators also collected the blood sample of each enrolled patient for advanced study.
Source: Centre Hospitalier Universitaire de Saint Etienne
Renal cancer is frequent and its diagnosis mainly dependant on imaging. More than 50% of
renal tumors are currently diagnosed without symptoms. However, 20% of small solid tumors
are benign and this percentage is much higher in atypical cystic tumors Bosniak II and III,
where 76% and 59% are benign respectively. Determining the malignancy by imaging in these
cases is difficult and sometimes impossible. The fine needle aspiration (FNA) cytology or
biopsy is ... Read More
Vulvar cancer is a rare and very aggressive cancer, mainly spreading through lymphatics, in
which the preoperative evaluation is critical to address surgery between sentinel node
biopsy or radical groin lymphadenectomy.
To compare the effects of conventional cytology testing with concommitant HPV-cytology
testing for the detection of high grade cervical lesions in primary cervical cancer
screening in Hong Kong
1. There is a significant difference in the number of CIN2+ cases detected between the
cytology testing group and the cytology-HPV co-testing group at baseline.
2. Significantly more CIN2+ cases will be detected at the second round of ... Read More
Source: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rationale: Cystoscopy and cytology, the current 'gold standard' for detection and follow-up
of primary and recurrent bladder cancer have some limitations. CLE, a high resolution
imaging technique, that can be used combined with endo-urological procedures, seems
promising to improve diagnosis of bladder cancer. The diagnostic accuracy of cystoscopic
applied confocal laser endomicroscopy (CLE) still has to be defined.
Objective: To directly correlate CLE ... Read More
The purpose of this prospective study is to compare the diagnostic utility of two techniques
(brush cytology + FISH and brush cytology + free DNA analysis) in the diagnosis of biliary
strictures. Histologic diagnosis (biopsies) in conjunction with clinical and/or imaging
follow-up will serve as the gold standard for diagnosis of malignancy. In order to do this
the investigators will ask study participants to have a small volume of fluid obtained from
the ... Read More
Acromegaly is frequently associated with impaired glucose tolerance and diabetes. We
hypothesise that pituitary histopathology and plasma hyperprolactinaemia could have
prognostic value in predicting the risk of glucose metabolic disturbances in acromegalic
patients. The aim of this study is to examine glucose metabolic outcome in acromegalic
patients with and without histologically verified prolactin and growth hormone (GH)
co-secreting adenomas. The study ... Read More
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use
of ACAPHA, a combination of six herbs, may prevent lung cancer from forming in former
smokers with bronchial intraepithelial neoplasia.
PURPOSE: This randomized phase II trial is studying the side effects and how well ACAPHA
works in preventing lung cancer in former smokers with bronchial intraepithelial neoplasia.
Purpose: To assess equivalence between low cost manual liquid based cytology (pap smear) and
standard Thin prep cytology screening.
Participants: 100-120 healthy women presenting for standard pap smear screening
Procedures (methods): After routine care pap smear, another pap smear will be performed and
placed in the study medium. Clinical care pap and study pap will be reviewed by a single
pathologist to assess for equivalent findings.
Hypothesis: ... Read More
The purpose of the study is to investigate the contribution of molecular cytological
analysis (CMA) and shear wave elastography ShearWave (SWE) in the diagnosis of nodules with
indeterminate cytology (IC)
Bladder cancer is a well-recognized complication in spinal cord injury (SCI) individuals.
The observed incidence rates in SCI individuals are considerably higher compared to the
general population. Bladder cancer in SCI individuals tends to present at an earlier age
compared to the general population. Furthermore, bladder cancer in SCI individuals is more
commonly invasive and at a more advanced stage at the time of diagnosis compared to bladder
cancer in ... Read More
Gastric cancer with positive is defined as stage IV disease in 7th AJCC/UICC TNM staging
system. Controversy exists on the treatment of this part of patients. This trial aimed to
explore the optimal treatment strategy for stage IV gastric cancer with positive peritoneal
cytology as the only non-curable factor.
Fluorescence in situ hybridization (FISH) has improved the diagnostic performance of
cytology for evaluation of malignant biliary strictures in the US and Europe. The utility of
FISH for diagnosis of biliary strictures in Asia is currently unknown. The investigators
conducted a prospective study in 2 university hospitals to determine diagnostic performance
of FISH for the diagnosis of malignant biliary strictures in Thai patients.
Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that
inflammation of the uncinate process is associated with decreased ventilation and drainage
of the paranasal sinuses and consequently with the inflammatory process occuring in the