The aim of this study is to compare the incidence of genito-urinary function depression and
anastomotic leak in Laparoscopic Anterior Rectal Resection (LAR) with Total Mesorectal
Excision with Ligation if the Inferior Mesenteric Artery at the origin or preserving the
Left Colic Artery by a prospective randomized trial.
The purpose of this trial is to determinate the efficacy of Sunitinib in patients with renal
cells carcinoma metastasic or locally avanced in patints not candidates to inicial curative
- Design: non-randomized, open label, phase II clinical trial.
- Study population and disease: adult patients with metastatic or locally advanced
non-resectable adrenocortical carcinoma, confirmed histologically.
- Estimated number of patients: 15.
- Study drug: dovitinib (TKI-258), dosed on a flat scale of 500mg/day on a 5 days on / 2
- Treatment duration: study treatment period will be continued until disease ... Read More
This is a prospective, multicentric, phase II and feasibility study aimed to address early
and late side effects of hypofractionated ablative radiotherapy for oligometastatic patients
with lymph node metastases for genito-urinary, gastro-intestinal and gynaecological cancer.
Phase I / II, open, prospective, multicenter single-arm, Clinical Trial in two stages: in
the first stage it will determine the optimal dose of the combination of pazopanib and
interferon alfa-A2 in the treatment of patients with advanced renal carcinoma and a second
stage that will determine the efficacy of this combination measured in terms of response
ProtoChoice-P is a prospective multicenter trial to evaluate proton therapy in patients
suffering from prostate cancer. Primary aim of the study is a decrease of moderate or severe
genito-urinary or intestinal side effects (Common Terminology Criteria for Adverse Events
(CTCAE) 4.0 grade 2 or higher) by the use of proton therapy. Secondary endpoints contain
assessment of quality of life, biochemical recurrence and recurrence free survival as well
as overall ... Read More
To determine the adverse events and genito-urinary side-effect profile of focal therapy to
treat localised low to intermediate risk prostate cancer using irreversible electroporation
Prospective observational study to assess bone predictive biomarkers for TKI response in RCC
patients with bone metastasis and HRQoL with TKI in these patients as well as the
sensitivity and specificity of whole body magnetic resonance versus bone scintigraphy and
versus CT in the assessment of metastatic lesions at bone level and at other sites.
The purpose of this retrospective observational study was to analyze the effect of targeted
therapies administered as second-line treatment after failure of pazopanib as well as
increase the amount of information available on efficacy and safety of pazopanib as a
first-line therapy in practice usual for the clinical treatment of metastatic Renal
Many oral analgesic drugs such as nonsteroidal anti-inflammatory drug(NSAID) are used to
relieve pain from gynecological procedure and dysmenorrhea. Hyoscine-N-butyl bromide, an
antispasmodic drug are commonly used for relief of smooth muscle spasms and can use to
relieve genito-urinary spasm. Some studies reported hyoscine can't relieve pain in minor
gynecological procedures. So the efficacy of hyoscine use are still controversial and no
previous studies ... Read More
This is a clinical trial to evaluate the efficacy and safety of the drug vinflunine
administered after the standard treatment of the combination gemcitabine+cisplatin, when it
has reached stabilization or response of the disease, as the first treatment inmeditely
after the diagnosis of advanced or metastatic urothelial cancer.
This study evaluates the effect of adaptative Intensity-Modulated Radiation Therapy (IMRT)
in the treatment of locally advanced cervical cancer on acute genito-urinary (GU), and
gastrointestinal (GI) toxicities. Every patients will be treated according to the adaptative
Penile cancer is an uncommon disease, with devastating physical and psychological effects on
patients. Penile carcinoma even in advanced stages is responsive to several chemotherapeutic
agents. However, due to the low incidence of penile cancer, no large studies have been
reported concerning chemotherapy.
Various single agents were tested for activity en penile cancer in de 70s and 80s. Response
rates ranged from 10 to 27% with cisplatin, 20 to 21% with ... Read More
The purpose of this study was to determine the effects of nevirapine treatment on the
pharmacokinetics of methadone in HIV-1 infected, opioid-dependent adults who had been on a
stable methadone maintenance therapy for at least five days prior to study entry.
This is a multicenter open label non randomized phase II clinical trial of Weekly
Cabazitaxel for Advanced Prostate Cancer in Hormone-Refractory Patients Previously Treated
The purpose of this study is to evaluate the activity of the weekly administration of
cabazitaxel as time to progression by PSA at week 12.