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Clinical Trials: Clinical Pharmacology & Toxicology


Source: Fraunhofer-Institute of Toxicology and Experimental Medicine
This study is aiming at evaluating whether low frequency ultrasound spectroscopy is a sensitive tool to detect broncholytic effects in patients with obstructive airway diseases. Read More
Last Updated: 22 Jun 2011
Source: Johns Hopkins University
Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of orally consumed intact cannabis (e.g., cannabis-containing brownies). Careful analysis of oral cannabis dose effects on these parameters is required to determine the level and duration of biological cannabinoid exposure and associated subjective, cardiovascular and cognitive effects. The present study will evaluate the detection of cannabinoids in oral fluid, plasma, ... Read More
Last Updated: 19 Oct 2015
Source: Pierre Fabre Medicament
Evaluation of the antinociceptive effect of 7 weeks of treatment with milnacipran, compared to placebo, in fibromyalgia out-patients Read More
Last Updated: 09 Jul 2013
Source: University of Zurich
Main Study Objectives: The study is conducted to - evaluate the minimal allopurinol and azathioprine doses that, in combination, produce therapeutic 6-TGN levels - evaluate the safety and tolerability of the different allopurinol/azathioprine dose levels - assess if concomitant allopurinol affects TPMT activity - assess the clinical efficacy of concomitant allopurinol-azathioprine therapy in the included ... Read More
Last Updated: 05 Feb 2012
Source: Korea University Anam Hospital
To compare the relative bioavailability and pharmacokinetic characteristics of a newly developed bepotastine formulation, bepotastine salicylate, with a conventional formulation, bepotastine besilate, in healthy subjects with a single dose, randomized, open-label, 2-sequence -2period crossover study. Read More
Last Updated: 10 Jul 2013
Source: Beijing Institute of Pharmacology and Toxicology
The purpose of this study is to explore the therapeutic efficacy of Favipiravir, a broad-spectrum antiviral drug against severe cases of Ebola Virus Disease (EVD), which is the most difficult aspect for clinical management of EVD due to its high fatality rate. Read More
Last Updated: 20 Jan 2016
Source: University of Zurich
The study is conducted to assess the effect of a vitamin D3 supplementation on the activities of two intestinal transporters and on the pharmacokinetics of the transporter substrates folic acid and fexofenadine. - Trial with medicinal product Read More
Last Updated: 08 Aug 2013
Source: Laboratorios Silanes S.A. de C.V.
The purpose of this study is to determine the gastric tolerability and the pharmacokinetics of a new drug for the treatment of type 2 diabetes, DMMET-01, in healthy volunteers. Read More
Last Updated: 13 Aug 2009
Source: Orion Corporation, Orion Pharma
The purpose of this study is to show that higher minimum concentration values are obtained following repeated doses of Stalevo 4 times daily compared to lecodopa/carbidopa treatment with corresponding dosing regimen. Read More
Last Updated: 05 Jun 2008
Source: New Mexico Cancer Care Alliance
This is a phase I and pharmacology study of Camptothecin-20-O-Propionate Hydrate (CZ48) in Patients with Solid Tumors or Lymphoma. OBJECTIVES Primary: 1. To describe the dose limiting toxicities and adverse event profile of Camptothecin-20-O-Propionate hydrate (CZ48) administered orally every day. 2. To determine Phase II recommended dose of Camptothecin-20-O-Propionate hydrate (CZ48) administered orally every day. ... Read More
Last Updated: 15 Jun 2015
Source: Akron Children's Hospital
Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs. IV treatment and the effect of a Clinical Pharmacology and Toxicology division in the management of APAP ingestions. Read More
Last Updated: 01 Nov 2011
Source: University of Zurich
In this study, pharmacologic effects of COMT inhibition during sleep deprivation in healthy subjects in dependence of their Val158Met genotype of COMT are studied. Potential effects are identified by measurement of vigilance and cognitive performance as well as EEG measurements during wake and sleep. - Trial with medicinal product Read More
Last Updated: 10 Sep 2014
Source: Johns Hopkins University
This primary aim of this study is to assess the effects of active versus passive (second-hand) inhalation of cannabis smoke on toxicological analysis of "native" oral fluid (saliva) and blood specimens. The results of this study will help inform the validity of oral fluid as a biomarker of cannabis exposure and to determine whether, and for how long, passive inhalation of cannabis smoke could result in a positive toxicology result. Read More
Last Updated: 02 Dec 2013
Source: University of Zurich
The blood concentration of the antibiotic colistin is determined in patients in whom kidney function is reduced such that a renal replacement therapy is needed. Hypothesis:no dose reduction is needed in patients undergoing continuous renal replacement therapy over 24h because colistin is sufficiently removed by this procedure. Read More
Last Updated: 05 Mar 2014
Source: Radboud University
The most powerful protective mechanism against ischemia-reperfusion injury other than rapid reperfusion is ischemic preconditioning. Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size. This mechanism can be mimicked by several pharmacological substances such as adenosine and morphine. We, the researchers at Radboud University ... Read More
Last Updated: 26 Mar 2008
Source: Laboratorios Silanes S.A. de C.V.
The purpose of this study is to determine the gastric tolerability and the pharmacokinetics of an extended release metformin compared with an immediate release metformin in healthy subjects. Read More
Last Updated: 21 Oct 2015
Source: University of Zurich
The proposed cohort study collected within a 5-month observation period adverse drug reaction (Adverse Drug Events - ADE) in patients at the Department of Oncology at the University of Zurich. ADE have been recorded using prospective monitoring and assessed using standardized algorithms regarding causality and severity. Data sources included information from the medical records, laboratory values and internal rounds. Additional information has been collected ... Read More
Last Updated: 26 Jan 2010
Source: University Hospital, Basel, Switzerland
The purpose of this study is to determinate the effect of a pre-treatment with centrally acting alpha2-receptor agonist clonidine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"). The investigators hypothesize that clonidine will attenuate the subjective and cardiovascular response to MDMA. Read More
Last Updated: 23 Jan 2013
Source: University of Zurich
Health care has an increasingly demand for mobile applications (App), but studies are rare, which explore the added value and benefits for patient and physician. Patients in different disease groups or physicians from different specialties are likely to have different demands. Research should focus on selected groups to better understand their individual demands. Our study intends to identify the added value of mobile symptom tracking in a selected subgroup ... Read More
Last Updated: 08 Dec 2015
Source: University Hospital, Basel, Switzerland
The purpose of this study is to determinate the effect of a pre-treatment with the combined serotonin (5-HT) and norepinephrine (NE) transport blocker duloxetine on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"). The investigators hypothesize that duloxetine will attenuate the subjective and cardiovascular response to MDMA. Read More
Last Updated: 23 Jan 2013
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