There is increasing evidence suggests that elevated levels of postprandial triacylglycerol
(TAG)-rich lipoproteins may promote the development of cardiovascular diseases (CVD). A
prolonged and elevated postprandial lipemia is associated with increased risk of CVD by a
variety of mechanisms such as insulin resistance, inflammation, endothelial dysfunction and
oxidative stress. However, current evidence on the acute effects of type of fats on
postprandial ... Read More
The goal of this clinical research study is to compare the technical quality of 2 ways of
performing endorectal magnetic resonance spectroscopy imaging (MRSI) of the prostate, using
a "3 Tesla (3T)" scanner. This is the first of a 2-part study. In Part 1, researchers will
compare the use of perfluorocarbon compound (PFC) within the endorectal coil with the use of
air in order to try to find out which technique may help to produce better-quality ... Read More
In this study, the investigators address the research question of whether palm olein will
have a positive influence on plasma total homocysteine levels in human volunteers provided
with high-protein diets formulated from common Malaysian foods.
Hypothesis: There is a significant difference on the effects of the three experimental oils
(palm olein, olive and coconut oil) on plasma tHy levels and the other markers of coronary
heart disease (CHD) risk ... Read More
The purpose of this study is to find out the Lidco Rapid ( monitoring tool gives cardiac
output) is as equivalent in determining the hemodynamic assessment in cardiac surgical
scenarios as the most often used pulmonary artery catheter, which is much more invasive than
the Lidco Rapid. This will be accomplished through online surveys which have different
cardiac surgery scenarios and will be distributed to cardiac fellowship trained
anesthesiologists. The ... Read More
Source: National Center for Research Resources (NCRR)
Traumatic Brain Injury (TBI) is the leading cause of acquired long term disability among
children and young adults. Deficits in attention and memory are common and persist for years
after moderate or severe TBI. The similarity between these symptoms and those of children
with AD/HD, the efficacy of methylphenidate in the treatment of AD/HD, and the efficacy of
methylphenidate in improving recovery of animals with brain injuries, support the need to
study ... Read More
The purpose of this study is to perform a descriptive, content-based analysis on the
different forms of documentation for in-flight medical emergencies that are currently
provided in the emergency medical kits on board commercial airlines.
RATIONALE: Stop-smoking information on the smokefree.gov website may help people quit
smoking and remain a nonsmoker.
PURPOSE: This clinical trial is studying how well the smokefree.gov website works with an
electronic bulletin board in helping United States federal employees quit smoking.
A multicentre, prospective observational study to develop, evaluate and validate Patient
Reported Outcome Measures (PROMs) for patients treated with cardiac ablation for symptomatic
The 40 resident study subjects will be randomized to either receive a training session on
use of a pocket-sized ultrasound or to receive training on physical exam skills. Following
these sessions the subjects will have the opportunity to practice their skills during
clinical rounds at BWH inpatient and outpatient settings. Four weeks after the training
session all study subjects will take part in an assessment of their diagnostic skills.
During this ... Read More
Patient undergoing breast reconstruction with lower abdominal flap, benefit when points are
used for membership (between the aponeurosis of the abdominal flap and underlying muscles)
for closing the donor area, where there is reduced incidence of complications.
Study to investigate the influence of remifentanil and glycopyrrolate on cardiac index and
blood pressure in children.To differentiate between contractility and the effect of the
circulating volume, some of the subjects will receive additional fluid.This will be
evaluated using two transthoracic echocardiac exams within the first 30 min of anesthesia.
This study will determine whether laparoscopic and open hernia repair have the same
recurrence and complication rates in the under 60yr old age group. The overall financial
costs of each repair will also be compared.
The primary objectives of this study are to evaluate the efficacy of ascending doses of
COR-003 in subjects with elevated levels of cortisol due to endogenous Cushing's Syndrome by
assessment of reduction in Urinary Free Cortisol (UFC) concentrations and to identify the
range of safe and effective doses of COR-003 that reduce mean UFC concentrations ≤ULN (upper
limit of normal) of the assay at month 6 of the maintenance phase of dosing without a prior
dose ... Read More
Aim: To evaluate the clinical survival of fluoride sealants applied in first permanent
molars affected by Molar-Incisor Hypomineralization (MIH).
Material and Methods: For this case control study, it was selected 41 first permanent molars
of the 21 children aged 6-8 years. MIH was classified by one calibrated examiner (kappa
0.80) according severity of the MIH lesion (EAPD, 2003). Inclusion criteria were FPM with
MIH or sound (without MIH), fully erupted, ... Read More
The purpose of this study is to determine whether addition of automated whole breast
ultrasound to the usual screening mammography in a population of asymptomatic women with
mammographically dense breasts will result in a significantly greater number of breast
cancers discovered than would be found by mammography alone.
This study will compare interscalene nerve block versus liposomal bupivacaine (Exparel) for
pain control after total shoulder replacements. Each method will be assessed in terms of
post operative pain scores, pain medication consumption, length of stay, complications
(nerve injuries, hematomas, cardiac/respiratory events) and rate of readmission due to pain.
The aims of this study will be achieved through a randomized controlled trial and
cost-effectiveness ... Read More
This study compared the efficacy at one year of an interdisciplinary approach including
individual counseling and group seminars versus group seminars alone to induce weight loss
in subjects at high risk of developing type 2 diabetes.
This study also compare if a participant's presence in small informative meeting groups as
the only form of intervention is sufficient to induce a lifestyle change, thus inducing the
weight loss needed for the prevention of ... Read More