The purpose of the study is to observe lacrimal fluid condition (tear film break-up time)
chronologically after a single dose of AL-43546 ophthalmic products（0.15%, 0.25% and
vehicle）and 0.1% sodium hyaluronate ophthalmic solution and compare lacrimal fluid retention
time between them.
This study is characterizing the subject-rated and behavioral effects of salvinorin A in
healthy volunteers. The investigators hypothesize the salvinorin A will have
Source: Nelson Marlborough Institute of Technology
This is a clinical research protocol to determine the feasibility of assessing lead levels
in hunters who use lead projectiles. This study will determine if it is possible to perform
an interventional double-blind placebo-controlled study of lead levels in hunters using lead
or lead-free projectiles following consumption of self-harvested wild game. The hypothesis
for the subsequent study is that minute lead particles from shrapnel dispersed through the
... Read More
This study evaluates the biological markers of treatment of opioid dependent individuals
with an extended release formulation of the opioid antagonist naltrexone. The biological
measures include functional MRI, blood levels of naltrexone and its metabolites, urine
toxicology and behavioral tests probing various aspects of personality, memory, reward
processing and attention.
SQ109 was developed with the aim of shortening TB treatment and providing new drugs for
resistant TB. The drug has demonstrated efficacy in toxicology studies and an acceptable
safety profile in first-in-man studies. The objective of this study is to evaluate the
extended early bactericidal activity (EBA), safety, tolerability, and pharmacokinetics of
several doses of SQ109 with or without Rifampicin (RIF) for 14 days in adults with newly
diagnosed, ... Read More
In case of sepsis, the therapeutic success is strongly influenced by the choice of
anti-infectives (AI) in terms of spectrum, dosage and administration schedule. It is
therefore critical to achieve adequate AI concentration as quickly as possible.
This protocol aims to define a common framework to studies conducted jointly by the
Antimicrobial Stewardship Team and the Pharmacology department of Cochin hospital for
various AI in a range of specific study ... Read More
A single oral dose study in subjects with hepatic impairment and healthy control subjects.
Subjects will stay at the clinical facility where interval blood samplings will be obtained
and examined for drug effect.
Source: Organization to Achieve Solutions in Substance Abuse (OASIS)
We hypothesize that integrating drug treatment into HIV treatment will improve HIV outcomes
as well as drug treatment outcomes in heroin users. This study will test this hypothesis by
randomizing patients to two groups. The first group will receive HIV treatment and
buprenorphine treatment contemporaneously at their HIV clinic. The second group will receive
HIV treatment at their HIV clinic, and go to another facility to receive buprenorphine
treatment ... Read More
Source: National Institutes of Health Clinical Center (CC)
- This study is a companion biology study to NIH protocol 08-C-0080, A Phase II Trial of
R1507, a Recombinant Human Antibody to the Insulin-Like Growth Factor-1 Receptor for
the Treatment of Patients with Recurrent or Refractory Ewing s Sarcoma, Osteosarcoma,
Synovial Sarcoma, Rhabdomyosarcoma and Other Sarcomas.
- Analysis of tumor tissue and blood samples from patients with sarcomas who are
receiving treatment ... Read More
Ulcerative colitis is characterized by abnormal activation of, and damage to, the colon
epithelium, which is considered to be a central pathogenic mechanism. Activation of colon
epithelium cells in UC is associated with an abnormal high expression of Toll-like
receptors, including TLR-4, the major transducer of LPS, binding specifically the lipid A
portion of LPS. Alkaline Phosphatase binds and subsequently dephosphorylates LPS, thereby
eliminating the ... Read More
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the use of
tiagabine, sertraline, or donepezil for the treatment of cocaine dependence using a modified
placebo-controlled experimental design.