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Clinical Trials: Clinical Pharmacology & Toxicology


Source: Alcon Research
The purpose of the study is to observe lacrimal fluid condition (tear film break-up time) chronologically after a single dose of AL-43546 ophthalmic products(0.15%, 0.25% and vehicle)and 0.1% sodium hyaluronate ophthalmic solution and compare lacrimal fluid retention time between them. Read More
Last Updated: 04 Jan 2010
Source: Johns Hopkins University
This study is characterizing the subject-rated and behavioral effects of salvinorin A in healthy volunteers. The investigators hypothesize the salvinorin A will have hallucinogen-like effects. Read More
Last Updated: 20 Mar 2014
Source: Nelson Marlborough Institute of Technology
This is a clinical research protocol to determine the feasibility of assessing lead levels in hunters who use lead projectiles. This study will determine if it is possible to perform an interventional double-blind placebo-controlled study of lead levels in hunters using lead or lead-free projectiles following consumption of self-harvested wild game. The hypothesis for the subsequent study is that minute lead particles from shrapnel dispersed through the ... Read More
Last Updated: 14 May 2016
Source: University of Pennsylvania
This study evaluates the biological markers of treatment of opioid dependent individuals with an extended release formulation of the opioid antagonist naltrexone. The biological measures include functional MRI, blood levels of naltrexone and its metabolites, urine toxicology and behavioral tests probing various aspects of personality, memory, reward processing and attention. Read More
Last Updated: 25 Jan 2016
Source: Ludwig-Maximilians - University of Munich
SQ109 was developed with the aim of shortening TB treatment and providing new drugs for resistant TB. The drug has demonstrated efficacy in toxicology studies and an acceptable safety profile in first-in-man studies. The objective of this study is to evaluate the extended early bactericidal activity (EBA), safety, tolerability, and pharmacokinetics of several doses of SQ109 with or without Rifampicin (RIF) for 14 days in adults with newly diagnosed, ... Read More
Last Updated: 10 Jan 2013
Source: Bristol-Myers Squibb
The purpose of this study is to evaluate the exposure of rifabutin (RIB) when administered with atazanavir and ritonavir (ATV/RTV) Read More
Last Updated: 22 Jan 2013
Source: Abbott
The objectives of this study are to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ABT-384 in elderly subjects. Read More
Last Updated: 31 Oct 2010
Source: Shire
A Study to Evaluate the Pharmacokinetic Interaction Between SSP-004184 and Midazolam in Healthy Adult Subjects Read More
Last Updated: 15 Dec 2014
Source: Astellas Pharma Inc
To assess the Pharmacokinetics and pharmacodynamics of single doses of ASP1517 in renal anemia patients on hemodialysis. Safety and tolerability will be also evaluated in these patients. Read More
Last Updated: 15 Jun 2010
Source: Assistance Publique - Hôpitaux de Paris
In case of sepsis, the therapeutic success is strongly influenced by the choice of anti-infectives (AI) in terms of spectrum, dosage and administration schedule. It is therefore critical to achieve adequate AI concentration as quickly as possible. This protocol aims to define a common framework to studies conducted jointly by the Antimicrobial Stewardship Team and the Pharmacology department of Cochin hospital for various AI in a range of specific study ... Read More
Last Updated: 14 Dec 2016
Source: Intercept Pharmaceuticals
This is a phase 1 study to evaluate the safety of a single 10 mg dose of obeticholic acid (OCA) in healthy volunteers and patients with liver disease. Read More
Last Updated: 22 Oct 2013
Source: Robert Bosch Gesellschaft für Medizinische Forschung mbH
Aim of the study is the clinical validation of the metabolism and the pharmakokinetic of Clomifen in correlation to CYP2D6 and inhibition of CYP3A4. Read More
Last Updated: 22 Feb 2015
Source: Azevan Pharmaceuticals
This is a multiple dose clinical study to be conducted with SRX246 capsules to determine the safety, tolerability and pharmacokinetics of the drug over a 14 day dosing period. Read More
Last Updated: 16 Jul 2010
Source: Bristol-Myers Squibb
A single oral dose study in subjects with hepatic impairment and healthy control subjects. Subjects will stay at the clinical facility where interval blood samplings will be obtained and examined for drug effect. Read More
Last Updated: 28 Mar 2016
Source: Innate Pharma
The purpose of this study is to evaluate the anti-tumor activity, safety and pharmacology of two dose regimens (0.2 and 2 mg/kg)of IPH2101 in patients with Smoldering Multiple Myeloma. Read More
Last Updated: 10 Apr 2014
Source: Sunovion
To evaluate the long-term safety and tolerability of SEP 225289 in adult subjects with Attention Deficit Hyperactivity Disorder (ADHD) Read More
Last Updated: 09 May 2016
Source: Organization to Achieve Solutions in Substance Abuse (OASIS)
We hypothesize that integrating drug treatment into HIV treatment will improve HIV outcomes as well as drug treatment outcomes in heroin users. This study will test this hypothesis by randomizing patients to two groups. The first group will receive HIV treatment and buprenorphine treatment contemporaneously at their HIV clinic. The second group will receive HIV treatment at their HIV clinic, and go to another facility to receive buprenorphine treatment ... Read More
Last Updated: 23 Oct 2005
Source: National Institutes of Health Clinical Center (CC)
Background: - This study is a companion biology study to NIH protocol 08-C-0080, A Phase II Trial of R1507, a Recombinant Human Antibody to the Insulin-Like Growth Factor-1 Receptor for the Treatment of Patients with Recurrent or Refractory Ewing s Sarcoma, Osteosarcoma, Synovial Sarcoma, Rhabdomyosarcoma and Other Sarcomas. - Analysis of tumor tissue and blood samples from patients with sarcomas who are receiving treatment ... Read More
Last Updated: 23 Jan 2017
Source: AM-Pharma
Ulcerative colitis is characterized by abnormal activation of, and damage to, the colon epithelium, which is considered to be a central pathogenic mechanism. Activation of colon epithelium cells in UC is associated with an abnormal high expression of Toll-like receptors, including TLR-4, the major transducer of LPS, binding specifically the lipid A portion of LPS. Alkaline Phosphatase binds and subsequently dephosphorylates LPS, thereby eliminating the ... Read More
Last Updated: 29 Mar 2012
Source: National Institute on Drug Abuse (NIDA)
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the use of tiagabine, sertraline, or donepezil for the treatment of cocaine dependence using a modified placebo-controlled experimental design. Read More
Last Updated: 10 Jan 2017