Source: Rutgers, The State University of New Jersey
RATIONALE: Participating in a therapy program may enhance communication and intimacy between
men with prostate cancer and their partners.
PURPOSE: This randomized clinical trial is studying how well therapy enhances communication
and intimacy for men with early stage prostate cancer and for their partners.
Source: First Affiliated Hospital, Sun Yat-Sen University
The purpose of this study is to assess the impact of different parameters (voltage, pulse
width, frequency) of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor
symptoms in patients with Parkinson's disease (PD).
Source: Norwegian University of Science and Technology
The purpose of the study was to investigate whether regular moderate- or high-intensity
interval training can change the DNA methylation in a long-lasting state, and whether these
changes affect the gene expression. In addition, the investigators will determine whether
the intensity of the training could be an affecting factor of the possible DNA-methylation
change as well. The null hypothesis was that no such exercise-induced changes occur.
The purpose of this study is to learn how best to treat substance use disorders in an HIV
clinic setting. Specifically, the purpose of this pilot study is to learn if
extended-release naltrexone (XR-NTX) would be a feasible and acceptable treatment for
HIV-infected individuals with opioid or alcohol use disorders.
The main aim of this trial is to assess the response rate, the feasibility and toxicity of
the treatment with antigen loaded Dendritic Cell Vaccination in Prostate Cancer patients.
Furthermore we want to investigate biological responses by measuring markers of in-vivo and
The purpose of the study is to identify lifestyle factors associated with PCOS and
understand how diet and activity levels impact features of PCOS. The secondary aim is to
examine psychosocial factors (e.g., health beliefs) of women with PCOS.
The purpose of this study is to determine whether intravenous or oral iron are effective in
the treatment of postoperative anemia and iron deficiency in patients submitted in
Source: European Organisation for Research and Treatment of Cancer - EORTC
For the treatment of thyroid cancer with the so called targeted therapy the angiogenesis
pathway has several potential targets. The Receptors for Vascular endothelial growth factor
(VEGF) and especially VEGFR-2 is considered to be crucial for the initiation of the
formation as well as the maintenance of tumor vasculature.
In thyroid cancer these VEGF receptors (VEGFR-1, VEGFR-2), VEGF itself and receptors of the
fibroblast growth factor (FGF) and for the ... Read More
Two hundred and forty patients with multiple sclerosis who met the study criteria will be
enrolled in this randomized double blind placebo-controlled clinical trial.
They will randomly assigned to placebo or vitamin D treatment group. The total time of study
is 52 weeks and the vitamin D group will be treated by weekly 50000 International unit(IU)
vitamin D, while the other group will receive weekly placebo. The annual relapse rate and
EDSS will be compared ... Read More
The purpose of this study is to determine the safety and clinical effects of alternating
androgen deprivation therapy with testosterone therapy in men with recurrent prostate cancer
as first line hormonal therapy, to assess the effect of alternating therapy on quality of
life and metabolic changes associated with androgen-deprivation therapy.
Background & Aim: Bone marrow derived mesenchymal stem cells (BM-MSCs) have capacity to
differentiate into hepatocytes and anti-fibrotic effect in the experimental model. No study
was done in humans with alcoholic liver cirrhosis. The researchers investigated the
anti-fibrotic effect of BM-MSCs in alcoholic cirrhosis as Phase II clinical study.
Methods: Eleven alcoholic cirrhosis patients (M:F = 10:1) with Child-Pugh's class B and
maintenance of alcohol ... Read More
The purpose of this study is to determine the role of lymphadenectomy in advenced ovarian
cancer patients at the time of interval debulking surgery after neoadjuvant chemiotherapy.
Moreover it is a prospective trial, aimed to investigate the prognostic role of sistematic
lymphadenectomy in terms of percentage of micrometastases detected, morbidity (complications
rate), progression free interval, overall survival, recurrence pattern.
Source: Association for Innovation and Biomedical Research on Light and Image
The study population will be selected from the "Epidemiological study on the prevalence of
Age related Macular Degeneration in Portugal" (Protocol N. CC-01-2009) where retinal
photographic grading (current gold standard for AMD assessment) was performed to confirm AMD
diagnostic. This study provides a population-based sample in which precise and contemporary
information on the frequency of nutritional and lifestyle risk factors will be collected,
enabling to ... Read More
The purpose of this study is to demonstrate noninferiority (a new treatment is equivalent to
standard treatment) in terms of the percentage of patients who have plasma human
immunodeficiency virus-type 1 (HIV-1) ribonucleic acid (RNA) levels less than 400 copies per
mL after 48 weeks of randomized treatment with tenofovir disoproxil
fumarate/emtricitabine/rilpivirine (TDF/FTC/RPV) versus TDF/FTC/efavirenz (TDF/FTC/EFV).
The principal aim of this study is to evaluate the presence of changes in cervical
vestibular evoked myogenic potentials (VEMPc) after acute intake of caffeine in healthy
Secondarily, it wants to standardize normal values exam VEMPc in otorhinolaryngology service
of the hospital.
Ocular aberration may play a role in determining optical quality. Recently performed study
reported that ocular aberration of preocular tear film would be important factor in not only
diagnosing the dry eye but also determining the efficacy of treatment. Therefore, in this
study, the investigators will aim to prove the improvement of quality of vision via ocular
aberration changes indirectly after the proper treatment for moderate and severe meibomian
gland ... Read More
This study will assess the safety and efficacy of 700 μg dexamethasone Posterior Segment
Drug Delivery System (DEX PS DDS) Applicator System in patients with macular edema in a 6
month double-blind period versus sham followed by a 2 month open label period.
Source: Beijing Center for Disease Control and Prevention
The purpose of this study is to observe the adverse reaction ratio and hemagglutination
inhibition (HI) antibody positive rate, Geometric mean titer (GMT) of three brands split
influenza virus vaccine in different population.