The purpose of this study is to define the mechanism(s) through which Obstructive Sleep
Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic
syndrome. The investigators hypothesize that the sleep fragmentation and intermittent sleep
hypoxia which occur in OSAH patients promote oxidative stress and inflammation which in turn
lead to insulin resistance, dyslipidemia, abnormal vascular reactivity and other processes
which ... Read More
There is now a global epidemic of diabetes and obesity affecting more than 300 million
people worldwide with Asia in the forefront. In Hong Kong, diabetes affects more than 10% of
the population. Patients with diabetes have a 12—25% lifetime risk of developing a foot
ulcer.The abnormal metabolic milieus of hyperglycemia, hyperlipidemia, hypertension,
pro-thrombotic state and chronic inflammation in diabetes causes atherosclerosis.A
significant proportion of ... Read More
Source: Albert Einstein College of Medicine of Yeshiva University
This study will enroll 25 patients with kidney disease to evaluate the effects of different
doses of sodium bicarbonate (baking soda) on levels of bicarbonate in the blood, kidney
function and muscle strength. The investigators will also evaluate safety and tolerability
of different doses.
Drinking water is largely advocated for obesity prevention and management. Recent studies
have suggested that water has a thermogenic effect, this has not been examined in children.
In this study, we will measure the resting metabolic rate of 21 obese children before, and
during drinking cold (4 degrees centigrade)water for up to 60 minutes.
The objective of this study was to investigate from 3 sites (University of Connecticut,
University of Florida, and University of California, Irvine) whether enhancement of a
modified Mediterranean-style, low glycemic load diet (MED) with specific phytochemicals (soy
protein, phytosterols, rho iso-alpha acids and proanthocyanidins; PED) could improve
cardiometabolic risk factors in women with metabolic syndrome.
OBJECTIVES: I. Determine dietary macronutrient intake in children with Rett syndrome and in
II. Measure sleeping and awake metabolic rates in various positions, i.e., reclining,
sitting, and standing, by whole-room indirect calorimetry and isotope dilution.
III. Quantify activity patterns by time-motion studies using 24-hour activity records and
IV. Correlate 24-hour activity patterns with 24-hour heart rate ... Read More
The main purpose of this study is to determine whether the opioid antagonist naltrexone is
helpful in ameliorating the weight gain and other adverse metabolic side effects experienced
by schizophrenic patients taking the second generation antipsychotic (SGA) Zyprexa.
Schizophrenics may have an altered/enhanced endogenous opioidergic drive, and because of
this, normally painful stimuli will be sensed as less painful in schizophrenics vs. healthy
controls. A ... Read More
This clinical trial is designed to provide additional information on the safety and
tolerability of vildagliptin (50 mg once daily (qd)) and sitagliptin (25 mg qd) when used in
patients with type 2 diabetes mellitus(T2DM) and severe renal insufficiency (Glomerular
filtration rate (GFR) < 30 mL/min) for a period of 52 weeks.
Source: Heilongjiang University of Chinese Medicine
The purpose of this trial is to investigate the effect and safety of auricular acupressure
on adolescent and young women with PCOS. Subjects will be randomly assigned in to two arms:
Auricular acupressure arm and placebo auricular acupressure, both arms will be treated for
three months. Body mass index, oral glucose tolerance test, hormonal profile and metabolic
profile will be determined.
Source: Albert Einstein College of Medicine of Yeshiva University
The purpose of this research is to study the effects of a medication called resveratrol on
the body's response to insulin (a hormone to control blood sugar), on inflammation and/or on
specific cells and processes in fat tissue, and on skeletal muscle metabolism and on brain
Source: Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
The purpose of this study is to determine whether the use of electroacupuncture to dredge
and regulate Dai Meridian combined with lifestyle modification are more effective than
lifestyle modification only in the treatment of anovulation and hyperandrogenism due to
polycystic ovary syndrome (PCOS) with abdominal obesity.Two thirds of participants will
receive electroacupuncture and lifestyle modification in combination, while the other one
third will receive ... Read More
Type of Study: Pilot, randomized and single center trial Test Procedure: Omentectomy Aim 1.
Determine the effect of omentectomy on 1) insulin sensitivity, 2) beta cell function and 3)
plasma markers of inflammation We hypothesize that removal of omental fat increases insulin
sensitivity and pancreatic sensitivity to glucose, and decreases systemic inflammation.
Aim 2. Identify genes and proteins in adipocytes from obese patients that ... Read More
The aims of the present study are to investigate the effect of vitamin K2 on bone turnover,
bone mass, bone structure, glucose metabolism, and arteriosclerosis.
Osteoporosis, diabetes, metabolic syndrome and cardiovascular disease are common diseases
that affect large groups of people in the Western world.
Our hypotheses is that vitamin K2 (MK-7) reduces undercarboxylated osteocalcin in
postmenopausal women and reduces bone turnover and increases bone ... Read More
The purpose of the study is to determine whether treatment of children and adolescents with
Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin
sensitivity and glucose tolerance.
Metabolic syndrome, labeled as the world's latest epidemic, is the force behind the global
epidemic of Type 2 Diabetes Mellitus and Cardio Vascular Diseases. This emerging epidemic is
an important public health problem for South Asians in their homeland and worldwide.
Pharmacological therapy is a critical step in the management of patients with metabolic
syndrome. In general, treatment for metabolic syndrome, that targets all or most of the
components of ... Read More
The purpose of this research study is to 1) understand how some, but not all people with
obesity develop obesity related conditions such as type 2 diabetes and cardiovascular
disease, and 2) compare the effects of 3 popular weight loss diets (Mediterranean,
low-carbohydrate, or a very-low-fat plant-based diet) in people with obesity.
"HIV lipodystrophy syndrome" (HLS) is characterized by loss of fat in the arms and legs,
with increase in fat in the abdomen, and abnormal blood lipid levels. Persons with HLS have
high risk for cardiovascular disease and diabetes mellitus and the metabolic syndrome. The
investigators have previously shown that the abnormal lipid levels and lipodystrophy in HLS
are associated with defective regulation of lipid metabolic rates, specifically, accelerated
... Read More
The human adipose and muscle -tissue produce and release a number of bioactive proteins
which contributes to the chronic low grade of inflammatory status which is associated with
obesity and plays an important role in the pathogenesis of type 2 diabetes and
Study 1: Our aim is to investigate if exercise has independent and additive effects in
combination with diet-induced weight loss on circulating levels of inflammatory markers ... Read More