This study is a multi-center, randomized, prospective open-label study to assess the
efficacy and safety of combination of peginterferon alfa-2b (40kD, Y-shape) and GM-CSF in
interferon-naïve chronic hepatitis B patients with HBeAg positive. Patients were randomized
to one of the 2 groups to receive different antiviral treatment.
This study is to investigate changes in brain activities in acute stroke patients , and to
correlate findings with clinical outcome measures. Another aim of the study is to
investigate whether transcranial direct current stimulation (tDCS) could improve motor
function in subjects with poor brain activity after stroke. The brain activity will be
measured by single and paired pulse TMS (transcranial magnetic stimulation). The study
... Read More
There are 2 parts to this study: Part 1 (dose escalation) and Part 2 (dose expansion).
The goal of Part 1 of this clinical research study is to find the highest tolerable dose of
the combination of bosutinib and inotuzumab ozogamicin that can be given to patients with
Ph+ ALL and CML in the lymphoid blast phase that also expresses CD22.
The goal of Part 2 is to learn if the dose found in Part 1 can help to control the disease.
The safety of this drug ... Read More
This study evaluates the value of a nursing symptom support en selfmanagement intervention
for adult patients with cancer treated with chemotherapy. Using a prospective sequential
design with a comparison group who receives standard care and a (later) intervention group
who gets the nursing intervention, we will evaluate the effect of this nursing intervention
on overall symptom distress (primary outcome) and other measures of symptom burden,
self-efficacy, ... Read More
Despite an increasing pharmacopoeia of effective medications for the treatment of bipolar
disorder, patient outcomes continue to be impacted by treatment adherence. Non-adherence to
treatments is also a major obstacle in translating efficacy in research settings into
effectiveness in clinical practice. Non-adherence with bipolar disorder (BD) medication
treatment dramatically worsens outcomes. Reasons for non-adherence among individuals with BD
are ... Read More
Expiratory flow limitation (EFL) occurs when flow ceases to increase with increasing
expiratory effort. In any circumstances EFL predisposes to pulmonary dynamic hyperinflation
and its unfavorable effects such as increased elastic work of breathing, inspiratory muscles
dysfunction, and progressive neuroventilatory dissociation, leading to reduced exercise
tolerance, marked breathlessness during effort, and severe chronic dyspnea. Our hypothesis
is that EFL ... Read More
The two specific aims of this study are: 1) to assess the impact of a genetic variant on
iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian
women. The investigators hypothesize that the genetic variant could enhance iron status and
iron absorption in Asian women.
Physical activity (PA) benefits both physical and psychological health, yet the majority of
UK adults are physically inactive. "Exercise for Health" (EFH) is a General Practitioner
(GP) exercise referral scheme run in Liverpool for people who are inactive with a medical
condition. Patients are referred by their GP practice, where they receive 12 weeks of
subsidised exercise classes at their local leisure or community centre.
In 2012, one of the thirteen EFH ... Read More
This study plans to learn more about the different ways used to treat tracheostomy
granulomas. Investigators want to see which standard of care method (steroid application,
silver nitrate, or betadine) is more successful in treating tracheostomy granulomas.
The investigators will apply non invasive Magnetic Resonance Imaging (MRI) techniques
developed in Nottingham to evaluate the gastric emptying, small bowel water content, colonic
gas and volumes in healthy volunteers eating three breads with different amount of gluten
(none, normal, or high gluten) in three consecutive weeks.
Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can function
as a type of "optical biopsy", providing non-invasive cross-sectional images of tissue
architectural morphology in situ and in real-time. This proposal will demonstrate that OCT
has the ability to provide novel and valuable histopathological information regarding donor
kidneys that can be used to predict post-transplant renal function. These investigations
will result ... Read More
The aim of this open, controlled, multicentre biomedical research study is to identify new
markers specifically associated with Horton's disease. This would make it possible to
improve the diagnosis and management of this disease.
Participation consists in taking one or several blood samples depending on the group
Hyperbaric oxygenation (HBO) involves breathing of 100% oxygen under elevated ambient
pressure. In correlation to the pressure level oxygen dissolves in the plasma resulting in
an increase of total oxygen in the body. The elevated tissue levels of oxygen may persist
for hours, instigating healing processes in wounds caused by disturbances in of perfusion in
small vessels, a condition often found in patient with diabetes.
We plan a prospective, double-blind ... Read More
This study is designed as a safety assessment to determine the cardiac and hemodynamic
effects of overuse of energy drinks in healthy individuals through ECG, heart rate (HR) and
blood pressure measurements. It will evaluate the use of a consumer available product that
is classified as a dietary supplement by the FDA.
Source: Korean Medicine Hospital of Pusan National University
Acupuncture is widely used for managing acute and chronic pain conditions. In the context of
an emergency department (ED), patients often present with non-emergent acute pain symptoms.
This may result in a delayed triage process and inefficient emergent management. An
integrative patient-care approach in emergency departments has been explored that may
improve patient satisfaction and promote efficient use of healthcare resources for
non-emergent patients in ... Read More