This study aims to evaluate the influence of genetic polymorphisms of OCTN1 and OCT2 and
other possible covariates on the kinetic disposition of GAB in patients undergoing GAB
chronic treatment. Thus, patients treated with GAB, for at least one week, are being
This is a Prospective open-label, comparative pivotal study with comparison of
self-assessments with blinded investigator assessments. Pregnant women attending the labor
and delivery unit of the hospital or emergency clinic and reporting unidentified wetness
(undetermined whether this is amniotic fluid leakage or urinary incontinence) will be
enrolled in this study. After informed consent is obtained, each subject will be given a
single AL-SENSE to use up to ... Read More
Several methods have been used to predict adhesions after abdominal operations.
High-resolution ultrasonography, magnetic resonance imaging and scar healing properties were
the methods that were evaluated in the English literature for this study. Estimating the
likelihood of adhesions and related complications after prior surgery and assessing the
severity of adhesion formation after surgery is not easy. Anticipating adhesions is very
important to preventing ... Read More
Source: H. Lee Moffitt Cancer Center and Research Institute
The purpose of this study is to test if an experimental drug called Durvalumab (Medi4736)
given by intravenous (IV) infusion is effective in treating carcinoma in situ (CIS) of the
bladder that no longer responds to Bacillus Calmette-Guérin (BCG) and to collect information
on the safety of these drugs and whether they cause any side effects.
Preoperative 5FU based chemoradiotherapy is still the standard of treatment for locally
advanced rectal cancer. About 15-20% of patients would achieve pathologic complete response
(pCR) after neoadjuvant CRT, and the survival outcome was much better than that of non-pCR.
We aimed to enhance the neoadjuvant treatment, adding mFOLFOX6 during CRT and after
radiotherapy, to improve the pathologic outcome and the survival outcome.
The goal of this clinical research study is to learn if adding panitumumab to the
combination of carboplatin and paclitaxel can help to control IBC when given before other
standard chemotherapy and surgery. The safety of these drug combinations will also be
The Child and Family Research Partnership (CFRP) will be conducting the "local" evaluation
of AVANCE's Fathers in Action/Padres Activos (FA/PA) fatherhood program. AVANCE is a
non-profit organization that has served low-income families and children since its founding
in 1973. AVANCE sites have been providing fatherhood services for some time, but the
programming offered has varied across sites and no rigorous evaluation of the programs has
been completed. ... Read More
The Ultra Q Reflex® (Ellex) constitutes the only Nd:YAG laser approved for the treatment of
vitreous floaters. No randomized controlled clinical trial has been carried out to this day
in order to investigate its superiority over sham treatment.
In the present study, 60 eyes will be randomized and blinded into 2 groups, one receiving up
to two sessions of laser vitreolysis the other scheduled for two sessions of sham treatment.
After a maximum of two (sham) ... Read More
The primary purpose of this study is to compare the time to prostate cancer progression
(pathological or therapeutic progression) between patients treated with enzalutamide versus
patients undergoing active surveillance.
The primary objective of the study is to assess the efficacy, safety, and tolerability of
epelsiban compared with placebo in treatment of women with adenomyosis.
This is a 12-week, randomized, double-blind, placebo-controlled, parallel group study with
an interim futility analysis. Subjects will be randomized 1:1:1 to receive 75 milligrams
(mg) of epelsiban three times daily (TID), 200 mg of epelsiban TID, or placebo TID. The
study will be composed of three ... Read More
Source: Federal State Budgetary Scientific Institution, Research Institute of Cardiology
The purpose of this study is to evaluate the management of chronic heart failure patients
with atrial fibrillation, to collect data on compliance with clinical guidelines and the
prevalence of long-term anticoagulant therapy,complications. The results will be used to
develop most rational therapeutic and diagnostic strategies to improve clinical outcomes of
Patellofemoral pain (PFP) is the most diagnosed condition in individuals with knee
complaints. Studies revealed that one third of individuals with PFP suffer from persistent
complaints, indicating that current treatments fail to prevent the chronicity of symptoms.
Considering that current treatment-strategies of patients with PFP seem to be unable to
avoid the development of chronic symptoms, the question arises if the underlying factors of
PFP are ... Read More
Source: The 476th Hospital of People's Liberation Army
Background: Effectiveness of Percutaneous transluminal angioplasty and stenting (PTAS) on
prevention of events of stroke and death in patients with symptomatic intracranial
atherosclerosis (ICAS) is controversial.
Aim: to determine whether PTAS plus medical treatment (MT) are superior to MT alone in
preventing events of stroke and death in patients with symptomatic ICAS.
Methods: The investigators will carry out a randomized controlled trial in 3 hospitals ... Read More
Human immune function and intestinal microbiota are suggested to be altered within
long-duration stay in space. Accumulated evidences on earth support that Lactobacillus casei
strain Shirota (LcS) is a promising probiotic strain on improvement of immune function and
intestinal microbiota. This study aims to investigate the impact of long-duration
spaceflight as well as intake of LcS on the international space station (ISS), on immune
system and intestinal ... Read More
Transobturator tapes (TOT) are placed according to the surgical technique described by
Delorme et al. in patients with a previous cervico-sacropexy (CESA) or vagino-sacropexy
(VASA). Before final Fixation of the tapes and suturing the vaginal skin a Hegar dilator
sound with either 8 mm or 6 mm diameter is placed in the urethra and a second Hegar dilator
sound with either 4 mm or 3 mm diameter is placed between the tape and the urethra. After
suturing the ... Read More
The purpose of this study is to examine the effect of standard dosing of cyproheptadine for
both cycled and continuous administration, as compared to no medication, on appetite
stimulation and growth in the pediatric gastroenterology feeding team patient population.
The secondary aim is to evaluate the effect, if any, of the suspected tachyphylaxis that is
commonly associated with cyproheptadine use. The third aim will be to examine the type and
duration of ... Read More
Attention Deficit/ Hyperactivity Disorder (ADHD) is a common childhood psychiatric
condition, which often persists into adolescence. In adolescence ADHD is associated with
poor academic, social, and emotional functioning, other psychiatric problems, substance
abuse, and antisocial behaviour. Although medication effectively reduces symptoms such as
hyperactivity and inattention, it does not directly address academic, social, emotional, and
behavioural ... Read More
Studying obesity and metabolic syndrome attention is focused more and more on gut
microbiota. In humans and animals, bariatric surgery (mainly gastric bypass surgery) lead to
alterations of gut microbiota, which seem to be favourable. In this study the investigators
aim to examine the effect of different bariatric procedures on composition of gut