This phase II study was designed to evaluate the safety, tolerability, and efficacy of
bevacizumab treatment in conjunction with PDT at the low fluence rate compared with
bevacizumab alone or combined with PDT at the standard fluence rate, in patients with all
types of choroidal neovascularization secondary to AMD.
Hypothesis: bevacizumab in combination with PDT (low and standard fluence rate) will i)
delay time to retreatment, ii) reduce the average number ... Read More
In this double-masked, vehicle-controlled, dose-response study, subjects will be randomized
to receive Netarsudil (AR-13324) Ophthalmic Solution 0.01%, 0.02%, and 0.04% or its vehicle
(one eye), q.d. (AM) x 7 days. The first dose and last dose will be administered in the
clinic. Ocular safety and ocular hypotensive efficacy will be evaluated in the clinic
throughout the study.
The objectives of this study are twofold
- To evaluate the safety and efficacy of 0.1% AGN-195263 administered twice daily
compared to its vehicle in patients with evaporative dry eye (EDE)
- To evaluate the systemic pharmacokinetics of 0.1% AGN-195263 administered twice daily
in patients with EDE
This study evaluates the use of topical cyclosporine 0.05% and sodium carboxymethylcellulose
0.5% for the treatment of dry eye disease in patients infected with the human
Twenty HIV-positive-patients were selected from the Department of Infectious Diseases of the
Federal University of Rio de Janeiro Hospital. Dry eye diagnosis was based on a dry eye
questionnaire (Ocular Surface Disease Index - OSDI®), Schirmer I Test, break up time ... Read More
The prevention and treatment of diseases via artificial intelligence represents an ultimate
goal in computational medicine. The artificial intelligence for systematic clinical
application has not yet been successfully validated. Currently, the main prevention strategy
for rare diseases is to build specialized care centers. However, these centers are
scattered, and their coverage is insufficient, resulting in inadequate health care among a
large proportion of ... Read More
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25%
ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented
clinical diagnosis of dry eye disease. The product will be studied over 14 days, with 1-2
drops instilled in each eye four times daily (QID).
Corneal transplant is a surgical procedure where a damaged or diseased cornea is replaced by
donated corneal tissue (the graft) in its entirety (penetrating keratoplasty) or in part
(lamellar keratoplasty). One type of lamellar keratoplasty is DSAEK (Descemet's Stripping
Automated Endothelial Keratoplasty), where only the damaged posterior section of the cornea
The purpose of this study is to investigate how immediate postoperative positioning ... Read More
Purpose: To determine whether a fluocinolone acetonide sustained drug delivery implant is
effective in the treatment of retinal vein occlusion that has caused persistent macular
edema and decreased visual acuity.
Hypothesis: A fluocinolone acetonide sustained drug delivery implant will be a safe and
effective method to treat patients with macular edema and decreased vision from retinal vein
The purpose of this study is to find a dose of intravitreal bevacizumab that is lower than
currently used for severe ROP, is effective in this study, and can be tested in future
Two intraocular irrigating solutions (BSSPlus versus Lactated Ringer's) are compared in this
prospective, randomized, masked trial to investigate for differences in preservation of
corneal integrity after phacoemulsification cataract surgery.
To evaluate the natural history of visual function in subjects with IRD phenotypically
diagnosed as Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP) caused by RPE65
or LRAT gene mutations.
To describe biocompatibility, postoperative results and complications after implantation of
the Corneal Quatrix Evolutive (Corneal, Croma, Austria) intraocular lens, a hydrophilic
acrylic intraocular lens (IOL) with 4-haptic design and 360° sharp optic edge.
The ocular surface may be the seat of an inflammatory process in many pathology as vernal
keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells
themselves and the constituent cells of the target organ, are the main factors that cause
inflammation. The main objective of our study was to compare the concentration of 40
cytokines in vernal keratoconjunctivitis and in control subjects.
To evaluate, specifically within the Canadian medical environment, the efficacy, safety and
cost-efficacy of ranibizumab administered either as combination therapy (ranibizumab plus
laser photocoagulation), or as monotherapy in comparison with the current standard of care
(laser photocoagulation monotherapy), in patients with visual impairment due to DME.