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Clinical Trials: Ophthalmology

Source: Tianjin Medical University
Retinal neovascularization of diabetic retinopathy might be associated with genetic risk factors and environmental risk factors. Read More
Last Updated: 25 Oct 2010
Source: University of Padova
This phase II study was designed to evaluate the safety, tolerability, and efficacy of bevacizumab treatment in conjunction with PDT at the low fluence rate compared with bevacizumab alone or combined with PDT at the standard fluence rate, in patients with all types of choroidal neovascularization secondary to AMD. Hypothesis: bevacizumab in combination with PDT (low and standard fluence rate) will i) delay time to retreatment, ii) reduce the average number ... Read More
Last Updated: 09 Jun 2008
Source: Aerie Pharmaceuticals
In this double-masked, vehicle-controlled, dose-response study, subjects will be randomized to receive Netarsudil (AR-13324) Ophthalmic Solution 0.01%, 0.02%, and 0.04% or its vehicle (one eye), q.d. (AM) x 7 days. The first dose and last dose will be administered in the clinic. Ocular safety and ocular hypotensive efficacy will be evaluated in the clinic throughout the study. Read More
Last Updated: 07 Jun 2016
Source: Allergan
The objectives of this study are twofold - To evaluate the safety and efficacy of 0.1% AGN-195263 administered twice daily compared to its vehicle in patients with evaporative dry eye (EDE) - To evaluate the systemic pharmacokinetics of 0.1% AGN-195263 administered twice daily in patients with EDE Read More
Last Updated: 06 Oct 2016
Source: Universidade Federal do Rio de Janeiro
This study evaluates the use of topical cyclosporine 0.05% and sodium carboxymethylcellulose 0.5% for the treatment of dry eye disease in patients infected with the human immunodeficiency virus. Twenty HIV-positive-patients were selected from the Department of Infectious Diseases of the Federal University of Rio de Janeiro Hospital. Dry eye diagnosis was based on a dry eye questionnaire (Ocular Surface Disease Index - OSDI®), Schirmer I Test, break up time ... Read More
Last Updated: 20 Nov 2008
Source: Sun Yat-sen University
The prevention and treatment of diseases via artificial intelligence represents an ultimate goal in computational medicine. The artificial intelligence for systematic clinical application has not yet been successfully validated. Currently, the main prevention strategy for rare diseases is to build specialized care centers. However, these centers are scattered, and their coverage is insufficient, resulting in inadequate health care among a large proportion of ... Read More
Last Updated: 20 Apr 2016
Source: The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
In this study the reproducibility of optical coherence tomography measurements should be evaluated. Read More
Last Updated: 20 Jul 2008
Source: Kala Pharmaceuticals, Inc.
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease. The product will be studied over 14 days, with 1-2 drops instilled in each eye four times daily (QID). Read More
Last Updated: 20 Oct 2016
Source: Oslo University Hospital
Corneal transplant is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft) in its entirety (penetrating keratoplasty) or in part (lamellar keratoplasty). One type of lamellar keratoplasty is DSAEK (Descemet's Stripping Automated Endothelial Keratoplasty), where only the damaged posterior section of the cornea is replaced. The purpose of this study is to investigate how immediate postoperative positioning ... Read More
Last Updated: 19 Sep 2010
Source: Duke University
Purpose: To determine whether a fluocinolone acetonide sustained drug delivery implant is effective in the treatment of retinal vein occlusion that has caused persistent macular edema and decreased visual acuity. Hypothesis: A fluocinolone acetonide sustained drug delivery implant will be a safe and effective method to treat patients with macular edema and decreased vision from retinal vein occlusion. Read More
Last Updated: 10 Dec 2012
Source: Jaeb Center for Health Research
The purpose of this study is to find a dose of intravitreal bevacizumab that is lower than currently used for severe ROP, is effective in this study, and can be tested in future larger studies. Read More
Last Updated: 26 Oct 2016
Source: University of Sao Paulo
Two intraocular irrigating solutions (BSSPlus versus Lactated Ringer's) are compared in this prospective, randomized, masked trial to investigate for differences in preservation of corneal integrity after phacoemulsification cataract surgery. Read More
Last Updated: 14 Dec 2008
Source: QLT Inc.
To evaluate the natural history of visual function in subjects with IRD phenotypically diagnosed as Leber congenital amaurosis (LCA) or retinitis pigmentosa (RP) caused by RPE65 or LRAT gene mutations. Read More
Last Updated: 27 Apr 2016
Source: National University Hospital, Singapore
To prove that external contact micropulse diode laser trabeculoplasty (EMDLT) can significantly lower intraocular pressure in cases of advanced open angle glaucoma. Read More
Last Updated: 12 May 2008
Source: The Eye Center and The Eye Foundation for Research in Ophthalmology
The purpose of this study is to compare flaremetry readings with the protein content of the aqueous humor and the clinical grading of flare. Read More
Last Updated: 28 Aug 2014
Source: General Hospital Linz
To describe biocompatibility, postoperative results and complications after implantation of the Corneal Quatrix Evolutive (Corneal, Croma, Austria) intraocular lens, a hydrophilic acrylic intraocular lens (IOL) with 4-haptic design and 360° sharp optic edge. Read More
Last Updated: 17 Nov 2010
Source: Carones Ophthalmology Center
Evaluate changes in tear film osmolarity and other DED signs/symptoms following treatment with IPL. Read More
Last Updated: 20 Dec 2016
Source: National Centre of Ophthalmology named after academician Zarifa Aliyeva
The objective of this prospective study is the treatment of esotropia by prescribing the full precise optical correction of refractive errors in children up to 3 years old. Read More
Last Updated: 25 Mar 2015
Source: University Hospital, Clermont-Ferrand
The ocular surface may be the seat of an inflammatory process in many pathology as vernal keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells themselves and the constituent cells of the target organ, are the main factors that cause inflammation. The main objective of our study was to compare the concentration of 40 cytokines in vernal keratoconjunctivitis and in control subjects. Read More
Last Updated: 05 Feb 2014
Source: Novartis
To evaluate, specifically within the Canadian medical environment, the efficacy, safety and cost-efficacy of ranibizumab administered either as combination therapy (ranibizumab plus laser photocoagulation), or as monotherapy in comparison with the current standard of care (laser photocoagulation monotherapy), in patients with visual impairment due to DME. Read More
Last Updated: 21 Oct 2014
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