In this research study of metabolic imaging in locally advanced rectal cancer, we hope to
learn whether new medical imaging technology can help predict the response of rectal cancer
to preoperative chemotherapy and radiation therapy. Ultimately we hope this information will
in the future help us predict which patients will benefit from more or less aggressive
initial therapy for their rectal cancer.
Obesity is a disease not always attributable to nutritional imbalance, frequently associated
with changes in key hypothalamic-pituitary (HP) axes. The regain of weight loss after
hypochaloric diets has been ascribed to these HP disregulations. The aim of the study is to
explore pituitary morphology and its association with pituitary function and metabolic
phenotype in outpatient obese individuals evaluated in the period 2010-2013 at the
Department of ... Read More
The purpose of the study is to determine whether antipsychotic treatment is influence
psychiatric patients due to endocrine and metabolic status and a quality of life.
The investigators expect, that 30-50% of patients will show pharmacon - gene induced weight
gain (> 7% of initial bodyweight) while the rest of patients will maintain unaltered
The purpose of this study is to learn more about what is the effect of uric acid on
oxidative stress and on the way the body metabolizes sugar in obese people. Understanding
this may lead to better diseases such as diabetes.
Patients with schizophrenia are more likely to have metabolic syndrome compared to general
population. The criterion for metabolic syndrome in Asian people including: elevated waist
circumference (male ≥ 90cm, female ≥ 80cm), elevated triglycerides ≥ 150mg/dL, reduced HDL
cholesterol: male < 40mg/dL, female < 50mg/dL, elevated blood pressure: ≥ 130/85 mmHg,
elevated fasting glucose: ≥ 100mg/dL. Several factors have been found to be associated with
metabolic ... Read More
The metabolic syndrome is associated with increased risk of cardiovascular disease and
diabetes mellitus. The age-adjusted prevalence of the metabolic syndrome in the United
States is 34% for men and 35% for women. Emerging alternative medicine worldwide led
investigators to evaluate the efficacy of Crocus sativus (Saffron) and Berberis Vulgaris
(barberry fruit) in treatment of metabolic syndrome. Serum total cholesterol, serum LDL
cholesterol, serum HDL ... Read More
The patient numbers with metabolic syndrome and diabetes have doubled in the last decade.
Data that physical exercise ameliorates the metabolic syndrome are convincing, although the
mechanisms of the effect in man are not clear. Numerous endocrine or molecular mechanisms
modified by physical exercise are known to be hypoxia-sensitive, i.e. by hypoxia-inducible
factor-1 (HIF-1) regulation. Thus, relative hypoxia may link physical exercise and
modification of ... Read More
Magnesium is the second most abundant ion in human cells and plays fundamental roles in
several enzymatic reactions: it is involved in ATP production, in the phosphorylation of
proteins, in glucose metabolism and in the contraction of cytoskeleton.
Several epidemiological studies demonstrated that low dietary magnesium intake is inversely
associated with diabetes mellitus, hypertension and metabolic syndrome.
Magnesium could be related to important ... Read More
Metabolic syndrome (MS) has an increasing prevalence worldwide and there is an urgent need
for improvement of medical treatment. In traditional medicine phlebotomy (blood letting) is
a recommended treatment for subjects with obesity and vascular disease. Recent studies
showed that blood letting with iron depletion may improve insulin sensitivity in patients
with diabetes mellitus. The investigators aimed to test if traditional blood letting has
beneficial ... Read More
Schizophrenia patients treated with clozapine have a high prevalence of obesity-related
metabolic syndrome. The condition is often poorly treated and may lead to the emergence of
coronary heart disease and type 2 diabetes. The study will investigate whether structured
treatment provided at the site of the outpatient psychiatric clinic of metabolic syndrome in
this population will decrease the severity of metabolic syndrome as compared with usual care
... Read More
Source: West Virginia School of Osteopathic Medicine
The purpose of this study is to identify salivary biomarkers for monitoring cardiometabolic
risk in children. The study hypothesis is that a combination of salivary biomarkers will
predict the presence of risk factors including impaired fasting glucose, hypertension and
dyslipidemia and will reflect changes in these risk factors over time.
The purpose of this study is to investigate whether low-dose simvastatin in combination with
ezetimibe in comparison to high-dose simvastatin alone, has a beneficial effect on the
function of the endothelium after an oral fat load in patients with metabolic syndrome.
Source: USDA, Western Human Nutrition Research Center
To determine if consumption of different diet plans that both are nutritionally-adequate and
provide energy to maintain body weight, alters fasting insulin concentrations, shifts other
common clinical markers of metabolic disease risk, and affects metabolomic profiles that
reflect glucose, lipid, and amino acid metabolism.
Source: Heilongjiang University of Chinese Medicine
Tanshinone was originally isolated from dried roots of Salvia miltiorrhiza bunge. In Chinese
medicine, this herb has been widely prescribed for several pathologies, including diabetes,
acne, cardiovascular disease.It has been demonstrated that the therapeutic benefit of
cryptotanshinone on prenatally androgenized rats may be mediated by its dual regulation of
key molecules during both insulin signaling and androgen synthesis.The purpose of this study
is to ... Read More
This is the first human treatment with PRX-102, an enzyme being developed as a long-term
enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease (alpha
galactosidase deficiency). The safety, tolerability, and exploratory efficacy will be
evaluated in this study of increasing doses. Patients will be treated with infusions every
two weeks for 12 weeks (7 infusions).