Background Statins are cholesterol lowering drugs that are prescribed to lower the risk of
cardio-vascular diseases. The use of statins has increased markedly and it is now one of the
most prescribed drugs in the world. 600,000 people in Denmark are taking statins on a daily
basis, 40 % of these are taking the medication without having any other risk factors for
cardio-vascular diseases than elevated blood-cholesterol i.e. they are in primary
... Read More
The important role played by the GI tract microflora on the metabolic health of an
individual are increasingly recognized. In this respect, the initial studies of Metchinkoff
that suggested a role of fermented food (specifically yoghourts ) to modulate the gut
microflora have evolved into the concept of "probiotics". Probiotics are living
microorganisms that bring a benefit to the host when administered in sufficient quantity
Here the ... Read More
Patients with Chronic kidney disease (CKD) with an estimated glomerular filtration rate
(eGFR) under 60 ml/min using the MDRD-6 (Modification of Diet in Renal Disease) formula
and/or CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formula should undergo
nephrological and urological care (diagnosis and treatment) to prevent chronic kidney
failure. This is recommended by the National Kidney Foundation Kidney Disease Outcomes
... Read More
Study B7451005 is a Phase 2 study which will assess the efficacy and safety of PF-04965842
in patients with moderate to severe psoriasis. The study will include three PF-04965842
groups (200 mg daily, 400 mg daily and 200 mg twice daily) and a placebo group. The
treatment period will be 4 weeks in duration and will be followed up by a 4 week follow up
Combination of continuous femoral block with parEcoxib vs placebo. Investigation of morphine
consumption, opioid sparing effects, VAS pain scores, haemodynamics, Anxierty scores,
transfusion requirements , Range of motion and rehabilitation parameters between two groups
The investigators are studying the difference between the history taken from parents prior
to their child's anesthesia to information gleaned routinely from a patient information
system called Ofek.
The goal of this clinical research study is to compare the effectiveness of liposomal
amphotericin B given three times per week , versus liposomal amphotericin B given once per
week, versus oral voriconazole in the prevention of fungal infections in patients with acute
myeloid leukemia (AML) or myelodysplastic syndromes MDS who are receiving chemotherapy. The
safety of these treatments will also be studied and compared.
Source: Princess Alexandra Hospital, Brisbane, Australia
The purpose of this study is to determine whether the incidence of recurrent life
threatening ventricular arrhythmias in patients with an implanted cardiac defibrillator
(ICD) can be reduced if a surgical left stellate ganglionectomy is performed.
This randomized clinical trial studies standardized geriatric assessment (GA) or usual care
in improving communication and quality of life in older patients with advanced solid tumors
or lymphoma and their caregivers. A GA measures the issues important to older patients,
including function, psychological status, cognitive abilities, social support, and the
impact of medical problems on quality of life. A GA may improve communication between
patients and ... Read More
Objective: To evaluate whether long-term oral N-acetylcysteine as an expectorant drug can
reduce the frequency of acute exacerbations of patients with non-cystic fibrosis
bronchiectasis and improve their quality of life.
Methods: Patients with non-cystic fibrosis bronchiectasis will be randomly assigned to the
observer group (participants receive 600 mg of oral N-acetylcysteine BID for 12 months) or
the control group (participants receive oral tablet BID ... Read More
Arrhythmias remain a major health problem, causing at least 250,000 deaths annually in the
United States. Pharmacological treatments often do more harm than good, and device therapies
are limited by high cost and effects on quality of life. Ion channel mutations cause rare
inherited arrhythmopathies, but account for only a small fraction of patients with life-
threatening arrhythmias and sudden death. Most arrhythmias occur during myocardial ischemia,
... Read More
To investigate the reported health benefits (lipid profile, inflammatory factors,
cardiovascular status and bone density) of a novel, phytoestrogen rich, Red Clover treatment
on women suffering from both menopause related primary (hot flushes, night sweats, sleep
disturbance and weight gain) and secondary (osteoporosis, cardiovascular and changes in
lipid metabolism) symptoms.
The objective of this randomized study is to compare the effect of two controlled chest tube
protocols on the duration of air leak and fluid drainage following pulmonary lobectomy or
segmentectomy by using an electronic regulated chest drainage system (Thopaz). Previous
studies have suggested that the amount of negative pressure used at the level of the chest
drainage device may affect the duration of air leak, but the results have been inconsistent,
however ... Read More
Sturge Weber Syndrome (SWS) is a rare disease that affects the patient's brain and causes
benign (non-cancerous) tumors to grow in the brain. One of the symptoms of SWS is epilepsy.
People with epilepsy have seizures. Some patients may also have eye problems and a red mark
on their facial skin.
This study is being done to find out if the study drug, everolimus, is safe and has helpful
effects in patients with SWS who have seizures and are not responding to ... Read More
Source: ZhuHai Cardionovum Medical Device Co., Ltd.
To evaluate the safety and efficacy of the paclitaxel-eluting peripheral balloon dilatation
catheter (LEGFLOW) compare to the PTA catheter (AMPHIRION DEEP).in treatment of inferior
genicular artery stenosis or occlusion.
Partially defective dental restorations might either be treated by complete replacement or
by repair of the affected region. Repair restorations are a scientifically proven approach
to manage failed restorations, but probably unknown to most patients. Results from this
study and findings on the predictors of patients' therapy decisions might improve future
patient information documents.
The goal of this study is to increase the efficiency of exposure in virtual reality (VR).
Based on the EMDR research the investigators would like to show that the implementation of
eye movements during the VR exposure results in a faster physiological relaxation response
among probands with spider phobia, which has a positive effect on the subjective and
behavioral efficacy of the VR exposure.