This study will evaluate the potential beneficial cardiometabolic effect of moderate (5%)
weight loss and progressive (5%, 10%, and 15%) weight loss in obese adults without diabetes.
Participants will be randomly assigned to one of 2 groups. Group 1: supervised weight loss
group (low-calorie diet). Group 2: supervised weight maintenance group (normal diet). Of
those assigned to group 1, half of the participants will lose 5% of their body weight and
the other ... Read More
The aim of the present study was to demonstrate the influences of three different treatment
strategies on biochemical parameters and testicular volume (TV) in patients with idiopathic
hypogonadotropic hypogonadism (IHH).
The purpose of this study is to test the hypothesis that the disruption of the "normal"
(three meals a day) eating pattern and prolonged overnight fasting caused by skipping
breakfast: i) alters the expression of specific clock genes and clock gene targets involved
in regulating adipose tissue lipolysis (breakdown or destruction); ii) increases basal
adipose tissue lipolytic (breakdown) activity and plasma free fatty acid (FFA)
concentrations; iii) reduces ... Read More
In peripheral blood; monocytes and macrophages are found in two phenotype; proinflammatory
M1 and anti-inflammatory M2 phenotypes. M2 form is converted (or polarized) to M1 phenotype
in various metabolic disorders such as obesity and type 2 diabetes mellitus.
The purpose of this study is to determine the effect of implantable contraception on the
incidence of diabetes mellitus in women with history of gestational diabetes mellitus
comparing with those using nonhormonal contraceptives.
This experimental study will compare impact forces and metabolic cost in runners (N=20; ages
18-45 years, who already use a forefoot strike running gait) in two treadmill running test
sessions (shod vs barefoot running)
The overall goal of this proposal is to characterize the immune cell profile of subcutaneous
abdominal adipose tissue in lean, overweight, obese and lipedema adults, and to evaluate
potential associations between different adipose tissue immune cell types and metabolic
Obesity and the metabolic syndrome in men are associated with a high prevalence of
hypogonadism of up to 50%. Increased fat mass leads to augmented release of adipocytokines
and pro-inflammatory cytokines such as IL-1-beta, IL-6 and tumor necrosis factor-alpha which
in turn suppress the hypothalamic-pituitary-gonadal (HPG) axis, leading to hypogonadism.
This pathophysiological interplay is termed hypogonadal-obesity-adipocytokine hypothesis.
TestIL is a ... Read More
The investigators will evaluate the effects of an endurance exercise program on the physical
performance, the well being, and indicators of metabolic function in patients with an HIV
The objectives of this clinical trial are to evaluate the effectiveness of an iridoid
enriched beverage containing noni and cornelian juices and olive leaf extract on advanced
glycation end product levels.
The purpose of this study is to analyze the effects of epidural anesthesia and analgesia on
intraoperative clinical outcome, postoperative recovery, metabolic changes, and immune
functions of the patients receiving open liver resection.
The purpose of this research is to provide a better understanding of how exercise (walking)
affects non-alcoholic fatty liver disease (NAFLD) in overweight people. NAFLD, which is
common in obese people, occurs when the liver has too much fat.
A diet with the multiple beneficial characteristics of whole grains and, more in general, of
"healthy cereals" favorably influences glucose and insulin metabolism in subjects with
metabolic syndrome. Therefore, the aim of the study is to evaluate the long term effects of
a diet containing "healthy cereals" versus a control diet, on glucose and insulin metabolism
in subjects with metabolic syndrome.
Source: National Institute of Mental Health (NIMH)
The study will compare the effectiveness of antipsychotic medications for patients with
schizophrenia or schizoaffective disorder for whom a medication change may be indicated
because of an increased risk of cardiovascular disease.
OBJECTIVES: I. Characterize the nutritional and metabolic profile of children and
adolescents with epidermolysis bullosa.
II. Determine patterns of body composition in these patients. III. Determine the energy
requirements of these patients by measuring resting energy expenditure.
IV. Assess protein nutrition by measuring lean body mass.
The purpose of this study is to determine whether consuming additional protein during
calorie restriction induced weight loss has beneficial or harmful effects on multi-organ
(liver, muscle, adipose tissue) insulin sensitivity, colonocyte proliferation rates, the gut
microbiome, muscle mass and function, and bone mineral density in obese, postmenopausal
Source: Heilongjiang University of Chinese Medicine
The present study is a randomized controlled trial, overweight/obese adolescent and young
PCOS subjects will be assigned into two groups: Taichi arm and control arm. Hormonal profile
and metabolic profile will be determined.