Alcohol leads to a leaky gut and translocation of bacterial products. This may lead to
inflammation and immune dysfunction as well as the typical hangover symptoms. Probiotics are
able to restore gut permeability and decrease bacterial translocation. A multispecies
probiotic may be able to restore gut permeability and decrease bacterial translocation as
well as inflammation, immune dysfunction and hangover symptoms after alcohol consumption.
Specifically, ... Read More
Source: University of Minnesota - Clinical and Translational Science Institute
The primary objective is to determine whether intralesional cidofovir is effective at
bringing about the total or near-total resolution of warts that have already proven
recalcitrant to standard therapy.
The secondary objective is to determine the tolerability of this new mode of administration
of cidofovir in the pediatric population
This open label investigation further evaluates the safety, efficacy and potential
mechanisms of action of a new form of electroconvulsive therapy (ECT). The investigators
have recently completed preliminary open-label studies with FEAST, first at Columbia
University, and then at the Medical University of South Carolina in Charleston (Nahas et
al., 2013b). The investigators have published the outcomes of the first 17 patients studied.
One patient withdrew ... Read More
Invasive fungal infections (IFI) in immunocompromised patients pose a major challenge for
diagnostics designed to permit timely onset of appropriate treatment. The aim of the current
clinical-diagnostic studies, one in in pediatric and one in adult patients at high risk of
IFI, is to test newly developed diagnostic approaches to invasive fungal infections in
relation to established procedures. The studies will be performed in a prospective, blinded
fashion, ... Read More
The purpose of this study is to evaluate the safety of enoblituzumab (MGA271) in combination
with Keytruda (pembrolizumab) when given to patients with B7-H3-expressing melanoma,
squamous cell carcinoma of the head and neck (SCCHN), non small cell lung cancer (NSCLC),
and other B7-H3 expressing cancers. The study will also evaluate what is the highest dose of
enoblituzumab that can be given safely when given with pembrolizumab. Assessments will also
be done ... Read More
This randomized, controlled study evaluates the efficacy of weigh loss interventions in
endometrial cancer survivors, using novel technology-based weight loss platforms. This is a
multi-site, pilot feasibility study which will provide preliminary data to support a larger
NIH funded, mult-center trial.
In this prospective, randomized trial subjects will be randomized to receive phenazopyridine
or no medication prior to pelvic reconstructive procedures that use cystoscopy to confirm
ureteral patency intraoperatively.
This study evaluates whether Helicobacter pylori eradication improves precancerous lesions
including glandular atrophy and intestinal metaplasia as well as new cancers or dysplasias
after endoscopic mucosal resection for gastric cancer.
The aim of this study is to assess the influence of the severity of chronic periodontitis on
hemodynamic parameters in hypertensive patients.Secondary purposes of this protocol is to
identify evolution of several biomarkers and correlate the clinical situation with oral
Myringotomy tube placement is one of the most commonly performed operations in children.
Emergence delirium after such procedures is common. During emergence delirium children can
become both a danger to themselves and others around them, including family members and
The primary objective of this study is to determine if acupuncture, when used in combination
with standard anesthetic management, decreases the incidence of emergence delirium ... Read More
The aim of the study is proof of concept and to establish the feasibility of performing a
study of resistive flexibility and strength training (RFST) in patients with asthma, with
the future goal of designing a larger randomized trial to test the hypothesis that RFST
leads to greater improvement in asthma symptoms, pulmonary function tests, range of motion
and connective tissue mobility compared with a control conventional physical therapy
Detecting scarred heart muscle is important to diagnose and treat of a wide variety of heart
conditions. Magnetic resonance imaging (MRI) can assess scarred heart muscle but it is time
consuming, contraindicated for some patients and not tolerated by others. Computed
tomography (CT) imaging has the potential to provide a rapid comprehensive assessment of the
heart. This study will assess CT imaging of the heart muscle of patients who have previously
... Read More
The purpose of this study is to compare the operative, anatomic functional outcome as well
as the subjective outcome of laparoscopic supracervical hysterectomy and sacropexy compared
to laparoscopic hysteropexy (conserving the uterus).
The investigators expect that both laparoscopic procedures are equal in regards to operation
time, complication rate, anatomic and functional outcome as well as subjective outcome.
This study will assess the safety and effectiveness of intratumoral plasmid interleukin-12
DNA injection (pIL-12) with electroporation (EP) in treatment-refractory metastatic and
unresectable squamous cell carcinoma of the head and neck (HNSCC). Intratumoral pIL-12 EP is
a gene therapy approach to directly induce a pro-inflammatory response within a tumor to
initiate and/or enhance anti-tumor immunity.
Depression is one of the most prevalent mental disorders to afflict adults. It seriously
impacts role functioning and often takes a recurrent or chronic course. Because most adults
who suffer from depression never receive treatment, there is a critical need to develop
interventions that can be easily implemented and widely disseminated. Interventions that
reduce the performance-impairing symptoms of subclinical depression and prevent the onset of
major ... Read More
This is a pilot study on the acute effects of nicotine-free hookah (herbal/steam stones)
smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking
is known to transiently increase blood pressure and heart rate while decreasing heart rate
variability suggesting - but not proving - sympathetic mediation. The contribution of
nicotine to these effects is unknown. Here the investigators will directly measure the acute
effects of ... Read More
This is a single-center, 1:1 randomized, double-blind, parallel-group, non-inferiority
controlled trial to demonstrate non-inferiority of CeraVe Baby Diaper Rash Cream compared to
Desitin Maximum Strength Original Paste when administered to children with diaper dermatitis
who are between 3 months to 18 months of age. Parents/caregivers of subjects in both groups
will administer the product with each diaper change throughout the course of the study
period. ... Read More
The investigators aimed to evaluate the effect of ultrasound guided thoracic paravertebral
block with bupivacaine on both perioperative anesthetic agent consumption and postoperative
analgesia in pediatric patients undergoing percutaneous nephrolithotomy for kidney stone.