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Clinical Trials: Ophthalmology

Source: University of California, San Francisco
In the First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial, the investigators propose to establish which immunosuppressive therapy, methotrexate or mycophenolate mofetil, is more effective as a first-line, corticosteroid-sparing agent for the treatment of non-infectious uveitis in a block-randomized, observer-masked, comparative effectiveness trial. Read More
Last Updated: 07 Jul 2016
Source: Allergan
This is a safety and efficacy study of abicipar pegol in patients with neovascular age-related macular degeneration. Read More
Last Updated: 18 Jan 2017
Source: London Health Sciences Centre
Introduction: Traumatic injuries to the outer covering of the eye (the cornea) are a common emergency department complaint. They cause significant patient distress including pain, loss of sleep and missed work days. There is currently no accepted, uniform approach to pain management in this patient population. Emergency medicine and ophthalmology texts state that prolonged use of medications that anesthetize the cornea is not recommended. Several recent ... Read More
Last Updated: 20 Feb 2008
Source: CoMentis
This is a Phase II randomized, double-masked study comparing the safety and efficacy of ATG003 (mecamylamine HCl) 1.0% and 0.3% ophthalmic solutions to placebo in patients with neovascular ("wet") age-related macular degeneration (NV-AMD). Read More
Last Updated: 25 Oct 2010
Source: Mati Therapeutics Inc.
Determine efficacy of the latanoprost punctal plug. Effect of configuration of L-PPDS placement on efficacy will also be examined. Read More
Last Updated: 15 Jan 2017
Source: University of Pecs
This study aims to assess if Lucentis injection applied into the eye is superior to conventional treatment concerning the prevention of visual loss in patients having clinically significant macular edema secondary to retinal vein occlusion Read More
Last Updated: 12 May 2010
Source: Hospital Hietzing
Acute anterior uveitis (AU) is a common reason for attendance at ophthalmic outpatient clinics. The painfulness and the fear of a transient or even persistent loss of vision may markedly reduce the individual's subjective well-being and pose a psychological burden. This study will test the hypothesis that during an attack of AU the patient experiences a marked reduction in psychological and physical well-being. Prospective, hospital-based epidemiologic ... Read More
Last Updated: 26 Nov 2011
Source: Santen Inc.
To investigate the dose-response relationship of DE-104 ophthalmic solution in lowering intraocular pressure (IOP) in subjects with Primary Open-Angle Glaucoma or Ocular Hypertension Read More
Last Updated: 31 Oct 2011
Source: The Eye Center and The Eye Foundation for Research in Ophthalmology
The aim of this study is to evaluate the efficacy of topical cysteamine eye drops in the treatment of corneal cystine crystals deposits in patients with nephropathic cystinosis. Read More
Last Updated: 08 May 2016
Source: University of Aarhus
Evaluation of the safety and efficacy of the Carl Zeiss Meditec VisuMax femtosecond laser for lamellar resection (ReLEx smile) in the reduction of myopia. Read More
Last Updated: 09 May 2016
Source: Bausch & Lomb Incorporated
The purpose of this study is to determine whether Vitrase (hyaluronidase for injection) is effective as a spreading agent for other injected drugs prior to ocular surgery Read More
Last Updated: 12 Mar 2013
Source: The Eye Center and The Eye Foundation for Research in Ophthalmology
The main purpose of this study is to describe the optical coherence tomography (OCT) findings in eyes with scleral inflammation and to differentiate cases with anterior scleritis from those with episcleritis and normal controls. Read More
Last Updated: 28 Aug 2014
Source: National Institute of Endocrinology and Diabetology, Slovakia
The aim of the study is to find out prevalence of diabetic macular edema (DME) in patients with diabetes mellitus in Slovak Republic.The outcome of the project will be epidemiology survey, prevalence of wet form of Diabetic Macular Edema in relation to duration of diabetes, type of diabetes, treatment (insulin vs. OAD or combination) etc. and identification of prognostic factors leading to development of DME. Read More
Last Updated: 11 Feb 2014
Source: National Eye Institute (NEI)
To evaluate the effectiveness of both argon laser photocoagulation and aspirin therapy in delaying or preventing progression of early diabetic retinopathy to more severe stages of visual loss and blindness. To help determine the best time to initiate photocoagulation treatment in diabetic retinopathy. To monitor closely the effects of diabetes mellitus and of photocoagulation on visual function. To produce natural history data that can be used ... Read More
Last Updated: 31 Aug 2006
Source: Shandong Eye Hospital
The purpose of this study is to determine whether tissue engineering conjunctiva is effective in the treatment of pterygium and atretoblepharia. Read More
Last Updated: 18 Sep 2016
Source: Szeged University
This study investigates the hypothesis that ranibizumab injection given into the eye is an efficacious and safe treatment option applied for swelling of the macula (site of sharp vision) in diabetes. Read More
Last Updated: 14 Oct 2009
Source: Bausch & Lomb Incorporated
The primary objective of this study was to investigate the efficacy of bromfenac sodium ophthalmic solution 0.09% for treatment of post-operative ocular inflammation in subjects who undergo cataract extraction and intraocular lens implantation. The secondary objective was to investigate the safety and tolerability of the same. Read More
Last Updated: 12 Mar 2013
Source: Medical University of Vienna
The purpose of this study is to assess the influence of vitrectomy on changes in central choroidea and comparing the results in imaging of the choroidea with two different OCT devices. This is a prospective, open, non-randomized, observational, MPG study This study will be performed at the Department of Ophthalmology, Medical University of Vienna. 40 Patients who undergo vitrectomy will be included into this study. The investigation will help to gain ... Read More
Last Updated: 25 Nov 2015
Source: Second Sight Medical Products
This post-market surveillance study is conducted in the European Economic Area where Argus II has been CE certified for use in outer retinal degeneration patients. This study is being conducted to monitor the use of Argus II in a larger population than available within pre-market approval studies. Safety data will be monitored to ensure continued acceptability of risks to study participants, and an attempt will be made to include all eligible and willing ... Read More
Last Updated: 19 May 2016
Source: Lahey Clinic
The purpose of this study is to compare the safety & effectiveness of the two types of cataract and glaucoma surgeries. Results from this study may improve the surgical and post surgical management and long term management of patients with these conditions in the future Read More
Last Updated: 20 Jan 2009
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