The overarching goal of this project is to explore whether associations exist between
metrics obtained from PET/MRI incorporating advanced MRI sequences and features of bladder
cancer, including grade, stage, and treatment response.
This study is developed to determine if the local anaesthetic dose can be reduced by the use
of intermittent bolus technique compared to continuous infusion when the nerve catheter is
placed underneath the paraneurium by ultrasound guidance in the popliteal fossa. Our primary
outcome is local anesthetic use the first 48 hours after connecting the peripheral nerve
catheter. Our hypothesis is that with an intermittent bolus less local anaesthetic is
necessary ... Read More
Source: Centers for Disease Control and Prevention
This study will be an open-label phase III randomized clinical trial comparing different
combinations and regimens of polio vaccines. The trial will compare one and two doses of IPV
administered at 6 weeks or 14 weeks or 6 and 14 weeks of age. All participants will also
receive bOPV at 6, 10 and 14 weeks of age.
The purpose of this study is to determine whether shockwave therapy is more effective in the
treatment of unspecific acute low back pain than sham therapy.
60 patients with acute low back pain will be recruited to a single-blinded, randomized,
placebo-controlled trial. They are randomized to receive either shockwave therapy or sham
treatment by a identically looking device for 4 weeks, twice a week. Additionally patients
receive physiotherapy twice a week ... Read More
To establish the bioequivalence of the new tipranavir oral solution formulation with the
current tipranavir oral solution formulation following single-dose administration. In each
case, 500 mg tipranavir was coadministered with 200 mg ritonavir.
Source: Northumbria Healthcare NHS Foundation Trust
This trials of cognitive stimulation therapy (CST) in Tanzania is part of the larger
Identification and Intervention for Dementia in Elderly Africans (IDEA) study.
The overall aim of the IDEA study is to set up and evaluate sustainable programmes to
facilitate diagnosis of, and therapy for, people with dementia led by local communities in
sub-Saharan Africa. The investigators seek to improve quality of life for people with
dementia and their caregivers.
... Read More
Study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BI
44847 following administration of multiple rising oral doses over 8 days in patients with
type 2 diabetes.
Between 6 and 16% of patients presenting to hospital emergency departments have infections,
with half of these having signs of systemic inflammation (known as 'sepsis'). A second issue
is that, at time of presentation, it can be difficult to determine who has inflammation as a
result of infection and who does not.
Some of the patients with infections will deteriorate to organ failure ('severe sepsis')
including failure of the heart and blood vessels to ... Read More
This study will compare mechanisms of action in two forms of brief psychotherapy for major
depressive disorder in adults. A treatment that targets deficits in motivation in depression
is expected to show greater improvements in motivation and pursuit of personal goals
compared to a second treatment that targets irrational thoughts that are typical in
Source: Sport and Spine Rehab Clinical Research Foundation
Cervical pain is a condition that affects 14.6% of all adults annually. Of this annual
prevalence, 37.3% experience persistent neck pain with periodic recurring episodes. The
purpose of this study is to compare muscle activation patterns of the cervical musculature
during exercises with elastic versus manual resistance in a neck pain and asymptomatic
populations. Methods: A convenience sample of 15 healthy, physically active participants and
15 current ... Read More
The study is performed to investigate the effect of the spacing device on the
pharmacokinetics of CHF 5993 pMDI active ingredients administered with and without
Aerochamber Plus Flow-vu antistatic VHC spacer as a single administration in COPD patients.
Moreover, the general safety and tolerability of the treatments will be evaluated.
The purpose of this study is to evaluate the relative efficacy and effectiveness of specific
components of cognitive behavioral therapies for insomnia: sleep restriction (SR) and
cognitive therapy (CT) in comparison to combined SR and CT (SR+CT).
Sickle cell disease (SCD) affects haemoglobin - the molecule in blood cells which carries
oxygen. It causes red blood cells to become abnormal crescent (or sickle)- shaped. Sickled
red blood cells cannot travel through small blood vessels as easily as normal red blood
cells which can lead to blockages. This means that oxygen may be prevented from getting to
where it is needed. Individuals with sickle cell disease also suffer form abnormality in the
lining of ... Read More
Source: Chelsea and Westminster NHS Foundation Trust
Burn injuries are a common presentation to A&E in the UK (175,000 per year) of whom 13,000
require hospital admission. Treatment of a single burn can cost more than £63,000, and is
ultimately dependent on the depth. Most burns are assessed by experienced clinicians within
a few days of injury. Accurate evaluation of burn depth can be very difficult with the naked
eye. Inaccuracy can lead to longer hospital stays, worse scarring and greater financial
costs ... Read More
Statins are cholesterol lowering medications that reduce the risk of cardiovascular events.
However adherence to these medications has been found to be lower among minorities, a group
particularly vulnerable for heart disease.
The purpose of this study is to compare the efficacy of a phone based behavioral
intervention to mailed educational materials regarding how to control cholesterol and other
risk factors. We hypothesized that the behavioral ... Read More
The study was done to evaluate the effects of the follicular and luteal phases of the
menstrual cycle on sedation level at loss of consciousness and bispectral index reach to 50
during propofol anesthesia, in patients with and without preoperative intravenous
Head and neck cancer would be suitable for quick diagnostic programs because their initial
symptoms are easy detectable and the curation rates in the initial stages are very high.
Actually the stages at diagnosis are about 30% in initial stages and 70% in advanced stages.
The hypothesis of this study is that a program for quick referral of patients with symptoms
of head and neck cancer would help early diagnosis.