In the current study, the investigators will evaluate intratumoral pharmacodynamic and
pharmacokinetic data associated with the administration of the HDACI, Panobinostat, among
recurrent GBM patients. In addition, this study will evaluate the safety and tolerability of
this agent, as well as evidence of anti-tumor activity in the patient population.
To generate additional long-term safety and efficacy data on flibanserin in premenopausal
women and establish long-term safety and tolerability of flibanserin in naturally
postmenopausal women with Hypoactive Sexual Desire Disorder who have completed a prior
clinical trial of flibanserin (Trial 511.130, 511.147, or 511.156).
Primary prophylaxis given less frequently initially, with the infusion frequency increased
if needed (Escalating Dose Prophylaxis), is likely to be less expensive and associated with
fewer complications than standard prophylaxis while reducing disability to a greater degree
than intermittent therapy.
To determine whether the combination of nifedipine GITS and valsartan is more effective in
reducing central blood pressure than nifedipine GITS or valsartan alone, and to determine
whether nifedipine GITS is comparable to valsartan
The investigators aimed to evaluate by the Sniffin' Sticks test the effects on olfactory
functions of nasal steroids and leukotriene antagonists used for allergic rhinitis.Thirty
patients with seasonal were included in this study. Patients were randomly divided into
three groups of 10 patients; group 1 received montelukast sodium and mometasone furoate
therapy, group 2 received only montelukast, and group 3 only mometasone furoate. Patients'
olfactory ... Read More
Recent research suggests that the skeletal muscles and the fibrous connective tissue form a
body-wide network of myofascial chains. A systematic analysis of dissection studies suggests
that fascia links at least a variety of muscles to myofascial chains (Wilke et al. 2015). As
fascia can modify its stiffness, strain transmission along these meridians is supposable
(Norton-Old et al. 2013). Tensile transmission along myofascial chains might contribute to
the ... Read More
Bioequivalence trial in healthy adult subjects to determine the bioavailability of 3
different sustained release formulations of naproxen 660 mg relative to the established
commercial Aleve 220 mg tablet.
The purpose of this study is to determine whether the combination therapy of CC-486 (oral
azacitidine) and pembrolizumab provides improved patient outcomes compared to pembrolizumab
alone in subjects with previously treated locally advanced or metastatic non-small cell lung
The platelet rich plasma (PRP) is a new and potential treatment for patients with kinds of
musculoskeletal disorders. Although few studies have showed beneficial effect of PRP for
regeneration of peripheral neuropathy in animal study, the associated study in human is
The purpose of this study is to evaluate the efficacy of electro-kinetically modified water
(EMW) beverage, consumed twice daily (BID) for 3 months in the management of endometriosis
associated pain, and to evaluate the effect of EMW consumption on analgesic use for
endometriosis associated pain.
Infant mental health is a significant public health issue as early adversity and expose to
childhood stress has life-long consequences for the affected children. Helping families at
risk correct their adverse effects on the infant has the potential to halt a negative spiral
effect where vulnerable parents fail to cope with an at-risk child - which in turn, adds to
the child's vulnerability, negatively affects the parents, and so forth. Over a four year
... Read More
Rationale: Online-grocery shopping is predicted to be one of the "hottest" food trends of
2014, as national retailers such as Amazon, as well as start-up companies, venture into the
e- commerce grocery sector. Importantly, the online-grocery environment could be uniquely
manipulated to promote healthier food purchasing and help with weight control. Since
consumers tend to choose items listed first on menus and buffet lines, the order of food
products ... Read More
This phase Ib combination study is being conducted to assess the safety and tolerability of
radium Ra 223 dichloride in combination with paclitaxel in cancer subjects with bone lesions
with special focus on Grade 3/4 incidence of neutro- and/or thrombocytopenia and exploration
of the mode of interaction (i.e. additive or synergistic interaction) between the selected
chemotherapy and radium Ra 223 dichloride with regard to myelosuppression.
The goal of this project is to determine whether an Internet-based weight loss program will
lead to weight loss and improvements in cardiovascular disease risk factors in people living
The purpose of this study is to determine whether the transplacental gradients for 6 polyols
and mannose are altered in intrauterine growth restricted (IUGR) pregnancies compared to
normal pregnancies and b) to determine the relative contributions of transplacental
transport vs production by the conceptus of both inositol (the major polyol) and mannose in
IUGR and normal pregnancies using stable isotopic methodology.
The aim of this prospective randomized double-blind study was to compare the analgesic
efficacy and the side effects of two doses of dexmedetomidine (1 and 2 µg.kg-1)
co-administered with bupivacaine with bupivacaine alone for caudal analgesia in children
undergoing infra-umbilical surgery.
The goal of this study is to increase and improve Goals of Care discussions for advanced
cancer patients by training medical oncologists to conduct these discussions. The
investigators will evaluate the GoC discussion's effects on patient satisfaction, receipt of
treatment in line with preferences, use of aggressive treatment, and oncologist