Use lay language. Oxaliplatin is a reference anticancer drug in the treatment of colorectal
cancer. However, its use is hampered by a specific neurotoxicity, which is characterized by
acute thermal hypersensitivity, notably to cold temperatures, and by chronic neuropathy
appearing with the repetition of chemotherapy cycles.
To this date there is no effective therapy able to prevent and/or to treat these adverse
drug reactions. So oncologists are sometimes ... Read More
A prospective case-control study was performed to investigate the effect of iloprost on the
intraoperative flow volume in diabetic and non-diabetic patients as well as the effect of
peripheral neuropathy in patients with peripheral arterial occlusive disease (PAOD)
undergoing arterial reconstruction (primary endpoint).
100 patients undergoing femoral artery reconstruction or femorodistal bypass surgery were
included. Prior to surgery, peripheral nerve ... Read More
The current study proposes to investigate Point of Care Testing (POCT) (Coagcheck®) and
compare obtained results versus standard laboratory coagulation parameters prothrombin time
(PT) and partial thromboplastin time (PTT). The time difference in obtaining the two results
will also be examined. A total of 100 pediatric patients undergoing spinal surgery or
cardiopulmonary bypass will be enrolled and consented per protocol. Blood samples will be
obtained ... Read More
This trial will assess the 6-month complete response rate and toxicity profile of oral
dovitinib therapy in BCG-refractory urothelial carcinoma patients with tumors with FGFR3
mutations or over-expression who are ineligible for or refusing cystectomy.
Source: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
The purpose of this study is to determine how a single dose of cyclosporin affects the
pharmacokinetics (ie, how the body affects the drug) of multiple doses of canagliflozin
(JNJ-28431754). The safety and tolerability of canagliflozin will also be assessed in
Evaluate visual outcomes and contrast sensitivity for subjects undergoing bilateral myopic
LASIK with a Nexisvision Shield or bandage contact lens placed postoperatively. Early speed
of visual recovery results indicate that the visual recovery in the first 4 hours after the
LASIK procedure show the most variability. A patient's ability to drive after their LASIK
procedure would potentially alleviate a challenge that patients often face in taking
additional ... Read More
This trial is conducted in Europe. The aim of the trial is to investigate safety,
tolerability and pharmacokinetics (the exposure of the trial drug in the body) of single
doses of NNC0113-0987 in healthy male subjects.
This is a multicenter, randomized, double-blind, parallel, placebo-controlled, multiple dose
study that will enroll approximately 40 systemic lupus erythematosus subjects with active
Source: American College of Radiology Imaging Network
This study will evaluate the importance of arterial stiffness and wave reflections as
determinants of persistent left ventricular (LV) hypertrophy and fibrosis (assessed using
cardiac magnetic resonance imaging [MRI]) after correction of severe stenosis of the aortic
valve. The hypothesis will test whether stiff arteries and increased wave reflections impede
pumping of blood by the LV after aortic valve replacement (AVR)and precent adequate
regression ... Read More
- To assess the effects on glycemic control of lixisenatide in comparison to placebo as an
add-on treatment to basal insulin with or without metformin in terms of HbA1c reduction over
a period of 24 weeks in insufficiently controlled type 2 diabetic patients.
- To assess the effects of lixisenatide over 24 weeks on :
- percentage of patients reaching HbA1c<7% or ≤6.5%,
- 2-hour ... Read More
The objective of this study was to investigate whether infants with total serum bilirubin >
450 umol/L in the neonatal period and no symptoms or no more than early acute bilirubin
encephalopathy develop long term sequelae with impairment of motor development, hearing and
executive function compared with a control group.
Objective: To assess the effect of bevacizumab on tumor vessels, and the reversibility of
the effect, using contrast-enhanced ultrasonography (CEUS) and histology in patients with
metastatic liver tumors derived from colorectal cancer.
Background Data: Direct evidence on the reversibility of any change in tumor vascularity
upon bevacizumab cessation in the clinical setting is lacking.
Methods: The study included 10 patients who received chemotherapy ... Read More
- A reduce in renal mass may result in remnant single nephron hyperfiltration, with
associated proteinuria and an accelerated loss of kidney function.
- Live-donor kidney transplantation is generally considered the best choice for patients
who have renal failure and are awaiting transplantation, because these kidneys function
better than kidneys from deceased donors, and waiting times for deceased-donor
transplants are long
... Read More
Foot surgery often causes severe and prolonged pain postoperatively. Prior methods of
postoperative pain control included oral narcotics, single injection regional techniques and
more recently continuous nerve catheters. Recent studies have demonstrated a benefit with
continuous popliteal catheters when compared to single injection techniques in regards to
postoperative pain control and patient satisfaction for foot surgeries.
Nerve blocks in the popliteal ... Read More
Malnutrition occurs in up to 50% of patients requiring elective surgery for neoplastic
diseases. It exerts a detrimental influence on outcome of surgery, because it can suppress
immune function, exaggerate stress response and cause organ system dysfunction. Increased
susceptibility to infection, protracted wound healing, impaired blood clotting and vessel
wall fragility have been shown to be the leading causes of postoperative morbidity and
mortality in ... Read More
After implantation of an Ahmed glaucoma valve in patients with glaucoma, hyperencapsulation
phase is an unwanted postoperative phenomenon, typically occurring with the free 3 months
postoperatively. When this does occur, it is treated with aqueous suppressant eye drops.
This study aims to determine if it is possible to reduce the rate of hyperencapsulation
phase. Patients in the treatment group will receive aqueous suppressant eye drops before the
... Read More
The amendment is designed to test the safety and efficacy of lower and higher doses of
Intravitreal (IVT) LFG316 using single and 18 successive monthly injections in patients with
geographic atrophy (GA). The study will also provide information on the safety,
tolerability, serum concentrations and pharmacodynamics of single and multiple IVT doses of
Using the NIH-funded Way to Health platform, the investigators will conduct this smoking
cessation randomized controlled trial (RCT) among CVS employees. The investigators will be
able to determine the comparative and absolute efficacy and effectiveness of 4 different
incentive structures that are each grounded in behavioral economic principles. Additionally,
the investigators will measure rates of and reasons for acceptance of each incentive
structure, and ... Read More