The purpose of the study is to determine the optimal surgical approach (ventral vs dorsal)
for patients with multi-level cervical spondylotic myelopathy (CSM). There are no
established guidelines for the management of patients with CSM, which represents the most
common cause of spinal cord injury and dysfunction in the US and in the world.
This study aims to test the hypothesis that ventral surgery is associated with superior
Short Form-36 physical ... Read More
The investigators will perform a phase I/II trial of Revlimid daily for 21 days and Abraxane
weekly for 3 weeks. Accrual will be on standard cohorts of 3 patients. Once the maximum
toxicity dose (MTD) is reached, the level below will be expanded to 25 patients for a pilot
phase II trial. All treatments will be performed until progression. Assessments will be made
at least at the 2, 4 and 6 month timepoints and monthly thereafter until progression.
The ... Read More
International, multicenter, long-term, follow-up study that will enroll HLH patients who
have received NI-0501 in a previous clinical trial, in the context of the clinical
development program for NI-0501
Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy
subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is
hypothesized that sniff dogs may be used as a tool in identifying cancer patients in the
high risk population or suspected patients. Trained dogs will sniff serum from participants
who are suspected to suffer from tumor by their physicians and not yet but will be diagnosed
by ... Read More
The SportWelding FijiAnchor is an absorbable suture anchor which is inserted by applying
ultrasonic energy. This provides an intimate bond between implant and bone delivering
The purpose of this study is to evaluate the surgical and clinical outcome of the
SportWelding Fiji Anchor in ligament repair of the hand and hand wrist.
The purpose of this study is to identify risk factors for thromboembolic and /or infectious
complications in 3,000 patients with solid tumor and receiving a Percutaneous Central Venous
Catheter (PCVC). A better understanding of the risk factors for these complications in this
population would then allow interventional studies to be proposed to assess the benefit of
prophylactic procedures in a sub-group of patients at most risk.
The main purposes of this randomized cross-over trial are to test if a 3h/day reduction of
time spent in sedentary behaviour (SB) through breaking up hourly and shifting it for
standing and walking behaviours would substantially increase total (TEE) and PA energy
expenditure (PAEE) compared to a week of habitual prolonged SB, in male and female
overweight/obese inactive (which do not attained MVPA recommendations) and sedentary desk
workers. Specifically ... Read More
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as
rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by
sugammadex. The investigators compare the intubating conditions, incidence of postoperative
myalgia (POM) as well as patient satisfaction for these two muscle relaxants.
Slow release iron capsules containing ferrous sulfate have been designed based on the
gastric delivery system. Iron absorption from those capsules administered with and without
meals will be measured using stable iron isotopes.
Background: The Portuguese National Health Directorate has issued clinical practice
guidelines on prescription of anti-inflammatory drugs and COX-2 inhibitors, acid suppressive
therapy and proton pump inhibitors, and anti-platelets. However, their effectiveness in
changing actual practice is unknown. The objectives will be to compare the effectiveness of
educational outreach visits in the implementation of clinical guidelines in primary care in
Portugal ... Read More
The investigators supposed that the complete video assisted ablation of pilonidal sinus
(VAAPS) could be an effective minimally invasive treatment of pilonidal sinus. This new
minimally invasive treatment allows the identification of the sinus cavity with its lateral
tracks, the destruction and the removal of all infected tissue and the removing of any hair.
The purpose of this study is to see if using a portable handheld ultrasound to guide
diuretic therapy for heart failure patients will prevent hospital readmissions. This study
will use a handheld ultrasound called a Vscan to look at a large vessel in the body called
the Inferior Vena Cava (a vein leading to your heart) . The study aims to see whether
changing diuretic therapy based on the size of this vessel will result in the less
hospitalizations for heart ... Read More
The rationale of this study is to investigate the effects of topical diclofenac on tumor
metabolism in the treatment of actinic keratoses in immunocompetent and immunocompromised
Study hypothesis is that topical diclofenac lowers lactate level in skin biopsies of actinic
keratoses. Planned number of patients is 38.
This study is a monocenter study investigating the effects of 3% diclofenac in 2.5%
hyaluronic acid gel on tumor metabolism in ... Read More
Source: Corporal Michael J. Crescenz VA Medical Center
The main objective is to test the hypothesis that inorganic nitrate supplementation will:
(1) Improve exercise efficiency and performance; (2) Enhance the systemic vasodilator
reserve during exercise and specifically, the vasodilator response in exercising muscle; (3)
Reduce arterial wave reflections and arterial load; (4) Improve skeletal muscle
mitochondrial function in subjects with heart failure with preserved ejection fraction.
The aim of this study is to compare sedation efficiency, safety and satisfaction by both
endoscopist, assistants, and the patients between continuous infusion and intermittent bolus
injection of propofol for deep sedation during ERCP.
This is an open Label, randomized, two-period, two-treatment, two-sequence, crossover,
balanced, single dose pivotal study. The purpose of this study is to assess the
bioequivalence between Test Product and the corresponding Reference Product under fed
condition in healthy adult human subjects.
The LMA Supreme (SLMA) is a single-use supraglottic device that provides a good seal for
positive pressure ventilation and good first attempt insertion rate of 98% in low-risk
patients undergoing Caesarean section. It has a double aperture design that facilitates the
introduction of an orogastric tube to aspirate gastric contents. The current practice is to
use endotracheal intubation with rapid sequence induction in general anaesthesia for
Caesarean ... Read More