This is a Phase I study to test the safety, pharmacokinetics and effectiveness of STM 434
alone, or in combination with liposomal doxorubicin, in patients with ovarian cancer or
other advanced solid tumors.
To gain knowledge about how patients undergoing prenatal diagnosis for a fetal abnormality
understand and react to Whole Genome Sequencing (WGS) testing, so that the investigators can
develop more ethical and responsible approach to patient education, counseling, and return
of results for patients.
Source: Sheffield Teaching Hospitals NHS Foundation Trust
In the future it is likely that we will replace the current schedule of injected vaccines
with interventions that interrupt transmission of infections in more subtle ways. The agent
that causes meningococcal disease (Neisseria meningitidis) colonises the nasopharynx of
individuals. In most people, the bacterium is harmless and survives for months in the
nasopharynx, however in a minority of people the bacteria can cause invasive disease.
Simply reducing ... Read More
The study investigates how safe ASP3652 is and how well it is tolerated when taken as
multiple doses. The study also assesses how quickly and to what extent it is absorbed and
eliminated from the body. In addition, the effects of age and gender are investigated.
The study consists of two parts. In Part 1 four dose levels are administered to four
separate groups initially. Two additional dosages are then investigated. Subjects receive
either a once-daily ... Read More
The principal aim of this study is to verify whether a program of supervised, multimodal
physical exercise improves cognitive function and/or reduces the rate of cognitive decline
in older adults
The effectiveness of Deep Brain Stimulation (DBS) in certain movement disorders is widely
demonstrated. The success of this procedure requires that the patient is awake and
cooperative. The conditions of this intervention can be difficult to tolerate by the patient
for several reasons: long procedure (from 3 to 8 hours), body immobilisation (particularly
the head in the stereotactic frame), stress related to the localization of the DBS. It is
therefore ... Read More
This non-interventional, multi-centric, cross-sectional study is aimed to determine the
prevalence of Chronic Kidney Disease in Indian patients with Type 2 Diabetes (T2DM). 3000
patients will be enrolled from 30 investigative sites all over the country. Each
investigative site will be expected to enrol 100 subjects. All the procedures will be
completed in a single day.
In this study, the investigators will examine the effects of buprenorphine, as compared to
placebo, upon physiological, subjective, and hormonal responses to a stressful speech task
and a non-stressful control task in healthy adults. There is strong evidence in support of
the role of endogenous opioids and opiates in mediating social behavior in humans and other
animals, and particularly, in social distress. The investigators have recently shown that
... Read More
The primary objective of this study was to compare the long-term (12-week) bronchodilator
efficacy and safety of ipratropium bromide / salbutamol combination administered by the
Respimat® 40 mcg / 200 mcg (one inhalation q.i.d.) to COMBIVENT Inhalation Aerosol (two
inhalations q.i.d.), ipratropium bromide Respimat® (one inhalation q.i.d.) and Placebo
formulations of each in patients with Chronic Obstructive Pulmonary Disease (COPD). An
additional objective ... Read More
Previous studies demonstrated that children served themselves more food when using larger
plates and bowels. The purpose of this study is to evaluate if self-served portions and
caloric intake in normal weight and overweight children will be influenced by a specially
designed eating plates compared to similar size normal plates.
The purpose of this study is to evaluate the effect of the sound processor upgrade from the
C-DACS investigational device Freedom sound processor to the Nucleus® CP810 sound processor
for the Codacs™ system on the speech reception threshold in noise, to evaluate the usability
of the Codacs™ Fitting Software, to evaluate the quality of life with the Nucleus® CP810
Sound Processor for the Codacs™ system, to collect long term data, to evaluate the
acceptance ... Read More
The National Register of Nephrology in 2007 shows, similarly to the European data, a problem
of a high mortality rate among Polish dialysis patients.
The main reason of death among chronically dialysis patients are cardio - vascular system
diseases. According to "The Report on the Condition of Renal Replacement Therapy in Poland
in 2007", these diseases are the cause of 53% deaths in Poland. The patients with chronic
kidney disease (PChN) are particularly ... Read More
- To evaluate whether the Scaffold is safe and demonstrates probable benefit for the
treatment of complete T2-T12/L1 spinal cord injury .
- This is a Humanitarian Device Exemption (HDE) Probable Benefit Study to demonstrate
safety and probable benefit in support of future studies and an HDE application with
The purpose of this study is to determine whether primary radiotherapy can be omitted for
the locally advanced rectal cancer with Magnetic Resonance Imaging (MRI) negative
The purpose of this research is to explore the relationship of metamemory and memory of
elders and to evaluate the effectiveness of a metamemory cognitive intervention on elders
with mild cognitive impairment and low memory self-efficacy.
HIV infection is associated with premature aging of the immune system. It is believe that
the persistent inflammation that accompanies HIV infection is a major contributor to
premature immune aging. Fish oil has well-documented anti-inflammatory properties. In this
randomized, clinical trial, we're testing whether a 12-week course of fish oil
supplementation will reverse premature aging in HIV-infected African American older adults.
The purpose of this study was to investigate whether combined assessment of lumbopelvic
control during sagittal and frontal plane motion (using two common clinical observational
assessments) discriminates between people with and without LBP than single plane assessment
alone. It was hypothesized that the two tests used in combination (multiplanar) would
perform better than each test used independently (single planar) in accurately
discriminating patient ... Read More
The objective of the study is to assess the efficacy and safety of PerioChip® (Chlorhexidine
gluconate chip) in the treatment of patients with Peri-implantitis.
The hypothesis of the study is that PerioChip® in adjunct to mechanical subgingival
debridement is more effective in the treatment of peri-implantitis when compared to the
common method of mechanical subgingival debridement alone. The primary efficacy measure will
be the reduction in probing pocket ... Read More
A standard treatment for your cancer is called FOLFIRINOX (this utilizes the FDA approved
chemotherapy drugs fluorouracil, leucovorin, oxaliplatin and irinotecan). In this study you
will receive the chemotherapy treatment FOLFOX-A (fluorouracil, oxaliplatin, leucovorin and
Abraxane ®) which substitutes irinotecan for the FDA approved chemotherapy drug Abraxane ®.
Even though Abraxane is FDA approved for pancreatic cancer, the combination of Abraxane with
the ... Read More