Patients with mechanical ventilation are in risk of malnutrition, which could lead to worse
outcome. According to guidelines released from authority organizations, enteral nutrition
(EN) should be prior approach for critically ill patients. However, initiation and delivery
of EN during the early period of ICU admission are frequently hampered, which results in
underfeeding. The investigators speculate whether an intensive enteral nutrition strategy
could ... Read More
A prospective, randomized and controlled study is proposed to establish whether an enteral
nutrition support regimen based on pressurized whey protein and glucose improves the
postoperative utilization of amino acid substrates compared to a drink based on glucose
alone. The kinetics of protein metabolism (protein breakdown, protein synthesis and amino
acid oxidation) will be investigated using stable isotope methodology before and after
surgery in patients ... Read More
This pilot study seeks to demonstrate the efficacy of an intravenous lipid preparation high
in omega-3 fatty acids (Omegaven) in the treatment of cholestasis in parenteral nutrition
dependent patients with short gut syndrome.
Colorectal cancer incidence is increasing at an alarming rate in China. Recent reports
concluded nutrition status and lifestyle factors were associated with colorectal cancer
risk, however, the influence of nutrition and lifestyle factors on cancer outcome in
colorectal cancer survivors is largely unknown.The investigators will explore the impact of
nutrition status, life style, dietary pattern, obesity, physical activity, depression,
diabetes, aspirin use ... Read More
Source: Centre Hospitalier Universitaire de Besancon
In malnourished patients in the palliative phase of cancer, the question is raised of the
relevance of implementing artificial nutritional assistance instead of oral feeding when
this is possible.
Medical prescription and implementation of artificial nutrition at this stage of the illness
seem less governed by data acquired by science than by subjective reasons (related to
beliefs, to a cultural or religious tradition, to the symbolic role of eating, to the ... Read More
Myeloablative allogeneic hematopoetic stem cell transplantation (AHSCT) are prone to
frequent secondary malnutrition to metabolic and digestive troubles due to conditioning
regimen, treatments (antibiotics, immunosuppressive therapy…) and graft complications (graft
versus host disease). In the absence of appropriate nutritional support, myeloablative
conditioning lead to a rapid serious denutrition. But, it is known as negative independent
prognostic factor ... Read More
The goal of the study is to determine if parenteral nutrition-associated cholestasis (PNAC)
is related to the amount of parenteral (intravenous) fat administered to premature babies
until full enteral nutrition is achieved.
Although it is demonstrated that nutritional support can improve clinical outcomes, the
literature shows that approximately 50% of cancer patients are not able to meet their
estimated energy requirements. Recent clinical studies suggest that a supplementary support
for parenteral nutrition (PN) could significantly help to improve the nutritional status of
malnourished cancer patients.
International guidelines recommend the use of PN in malnourished, ... Read More
Rationale: Enteral nutrition (EN) in the intensive care (ICU) patients is recommended as a
standard of care. However, EN alone is often associated with insufficient energy intakes and
increased complication rates. Recently the investigators proposed to decrease this deficit
by combining EN and supplemental parenteral nutrition (SPN) whenever EN is insufficient (<
60% of their predicted energy needs) at day 3 after admission in the ICU.
Objective: This study ... Read More
Source: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
The purpose of the study is to determine the tolerance on lipid metabolism and the safety of
short-term parenteral nutrition as compared to enteral nutrition in critically ill patients
with liver failure.
This study examines the hypothesis that administering intravenous fish oil, in lieu of
intravenous soybean oil, can ameliorate the progression of PN-associated cholestatic liver
disease in pediatric patients with elevated direct bilirubin requiring PN for more than 30
This is an expanded access protocol for use of intravenous fish oil infusion, Omegaven, in
infants and children with parenteral nutrition associated liver disease (PNALD) to decrease
elevated liver enzymes and direct bilirubin.
This study aims to describe the response of PNALD after use of Omegaven by normalization of
serum levels of liver enzymes and bilirubin.
Having previously demonstrated that supplemental parenteral nutrition to complete an
insufficient enteral nutrition (EN) between D4 and D8 improves outcome after critical
illness, by reducing infectious complications, the present trial aims at investigating the
underlying carbohydrate and protein metabolism changes, as well as the immune and
inflammatory modulations associated with this improvement.
We investigate the impact of taste receptors (sweet, bitter and umami) on human metabolism.
There ist growing evidence, that components of the taste signalling system, including the
taste receptor proteins , have important functions in the regulation of metabolic parameters
in non-gustatory tissues.
This study will determine if an education program about hygiene and child feeding practices,
taught by local village community health workers, will improve child growth and decrease the
prevalence of childhood malnutrition in a rural region of Kenya.
In this study, the investigators conducted research among HIV-infected and -uninfected
pregnant and lactating women to understand the potential role and importance of food
insecurity on participant physical and psychosocial health and nutrition.