Vitamin A Status and Risk of Excessive Vitamin A Intake Among Urban Filipino Children

NCT ID: NCT03030339


Title
Vitamin A Status and Risk of Excessive Vitamin A Intake Among Urban Filipino Children Exposed to Multiple Vitamin A Intervention Programs
Purpose
The goal of this study is to assess whether children 12-18 months of age who are exposed to multiple large-scale vitamin A programs, and who are likely to have vitamin A intakes above the tolerable upper intake level (UL), have higher total body vitamin A stores and biomarkers of excessive vitamin A status, compared to children 12-18 months of age who have adequate vitamin A intake.
Details
This is an observational study with 3 groups, which are identified using a screening tool to obtain information on exposure to vitamin A programs and consumption of vitamin A-rich foods and supplements. Children and their mothers are studied over the course of one month to determine 1) child total body vitamin A stores, using the 13C retinol isotope dilution method, 2) the child's vitamin A intake, using multiple dietary assessment methods, 3) total breast milk intake (among breastfeeding children), using the dose-to-mother deuterium dilution method, and 4) potential biomarkers of excessive vitamin A status, including markers of bone and liver health. Blood collection is structured in a "Super-Child" design, to construct plasma retinol kinetic curves. Other indicators related to vitamin A nutrition among children will be measured, in addition to the vitamin A intake and breast milk vitamin A concentration (for breastfeeding mothers) of the mother.
Conditions
Vitamin A Status
Keywords
Vitamin A status, infant, dietary assessment, retinol isotope dilution, breast milk intake
Source
University of California, Davis
Sponsors
University of California, Davis, Newcastle University, Penn State University, Helen Keller International, Philippines Food and Nutrition Research Institute, Global Alliance for Improved Nutrition, Bill and Melinda Gates Foundation, International Atomic Energy Agency
Status
Recruiting
Acronym
GloVitAS-P
Last Updated
19 Jan 2017
URL
Official Link
Locations
Philippines