Optimising FSH Dosage During in Vitro Fertilization Fertilization (IVF)

NCT ID: NCT02915900


Title
Method for Determining Optimal FSH Dosage During in Vitro Fertilization (IVF)
Purpose
During in vitro fertilisation (IVF) treatment, women receive hormone stimulation with gonadotropins to induce growth of several ovarian follicles. Selecting the optimal dosage of gonadotropin is important to avoid maturation of too few or too many follicles, which may impair the chances of treatment success, lead to treatment cancellation, or serious side effects. Motivated by the lack of standardised procedures to estimate the optimal dosage of gonadotropins, a patient-specific test has been developed to predict the optimal hormone dosage. By measuring internalisation of gonadotropin by the patient's monocytes isolated form the peripheral blood ex vivo, the Gonadotropin Removal Test determines whether a patient needs increased or reduced hormon doses. In this clinical study the investigators compare deviation from optimal outcome at oocyte pick-up day in two patient groups. Optimal outcome of stimulation is defined as 10 oocytes collected in the group of patients matching the inclusion criteria of the study. The control group receives starting hormone dosage assigned by the clinician according to standard clinical procedures. The intervention group receives starting hormone dosage adjusted according to the results of the Gonadotropin Removal Test.
Details
Conditions
Infertility
Keywords
In vitro fertilization
Source
Oslo University Hospital
Sponsors
Oslo University Hospital
Status
Enrolling by invitation
Acronym
Last Updated
22 Sep 2016
URL
Official Link
Locations
Norway