Using Exhaled Air to Determine Changes in Nutritional Status of Patients on Intravenous Nutrition
Changes in CO2-13/CO2-12 Delta Value in Exhaled Breath to Examine Changes in Metabolism in Patients Being Fed Intravenous Nutrition
Carbon-12 and carbon-13 are naturally-occurring isotopes that are found in exhaled breath.
Investigators have proved that the 13CO2/12CO2 breath delta value (BDV) changes in subjects
who were in negative energy balance then fed a positive energy balance meal. Measuring one
liter of exhaled breath daily may be a more convenient way to measure negative or positive
energy balance in patients receiving intravenous nutrition.
This is a prospective, pilot study to determine if there is change in the 12C/13C BDV
between days 0-7 in patients who receive parenteral nutrition. Investigators will recruit
subjects from inpatient units at the University of Wisconsin Hospital and Clinics whose
primary team consult the Nutrition Support Team to institute parenteral nutrition for
clinical reasons. Subjects with clinical indications for parenteral nutrition are moderately
to severely malnourished due to little to no nutrition by other means (oral nutrition or
nutrition per tube) for a period of time (0-10 days based on state of nourishment prior to
Investigators will record baseline nutritional status from the medical record notes
(dietitian, Nutrition Support Team, etc.), as well as medication, demographic information
and medical history. Investigators will take a baseline exhaled CO2 measurement and then a
daily measurement at approximately the same time daily (+/- an hour).
The daily exhaled 12C/13C breath delta value will be matched with the subjects' daily
caloric intake from parenteral nutrition (and oral nutrition and nutrition per tube, if
applicable). The breath delta value, the caloric intake, plus the subjects' degree of
malnourishment will be parameters with which to build further research. Investigators
hypothesize that the breath delta value will increase from baseline and then stabilize after
the patient reaches goal energy needs as defined by the Nutrition Support Team.
Obesity, Malnourished, Fasting
University of Wisconsin, Madison
University of Wisconsin, Madison, Isomark, LLC
Not yet recruiting