Influence of Fish Oil Based Intravenous Fat Emulsions on the Epidermal Barrier Function

NCT ID: NCT02550860


Title
Influence of Fish Oil Based Intravenous Fat Emulsions on the Epidermal Barrier Function
Purpose
The epidermal barrier efficacy is determined by the physicochemical properties of the epidermal lipid matrix, among which ω-6 essential fatty acids (EFAs) play a key role. Inversely, the ω-3 EFAs are not found in the epidermis. For patients receiving lipid-containing parenteral nutrition (LCPN), the improvement of the epidermal barrier through the infusion of most appropriate intravenous fat emulsions (IVFE) could have many applications in clinical nutrition, mainly limiting water loss in patients receiving long-term LCPN and help in electrolyte and water balance. The objective of this interventional clinical trial is to evaluate the epidermal barrier function in patients receiving long-term LCPN comparing two compositions of IVFE: (i) soybean oil (SO)-based IVFE (Medialipide) or (ii) fish oil (FO)-containing IVFE (Lipidem). Epidermal barrier function will be assessed through the transepidermal water loss (TEWL) measurement on the skin surface, a validated marker of the epidermal barrier efficacy. The two IVFE (SO-based or FO-containing) will be compared using a randomized double blind crossover design, using patients as their own control. Each IVFE will be allocated for a 3-month period, allowing sufficient timeframe for epidermal complete renewal. Patient's epidermal and red blood cell EFA profile will be determinate in order to facilitate result interpretation.
Details
Conditions
Intestinal Diseases
Keywords
intravenous fat emulsions, parenteral nutrition, skin barrier function, essential fatty acids, transepidermal water loss
Source
Hospices Civils de Lyon
Sponsors
Hospices Civils de Lyon
Status
Recruiting
Acronym
Tewlip
Last Updated
04 Jan 2017
URL
Official Link
Locations
France