Effects of a Probiotics on the Health of Normal Young Males
Study of the Effects of a Probiotic Yoghourt on the Metabolic Health of Normal Male Volunteers
The important role played by the GI tract microflora on the metabolic health of an
individual are increasingly recognized. In this respect, the initial studies of Metchinkoff
that suggested a role of fermented food (specifically yoghourts ) to modulate the gut
microflora have evolved into the concept of "probiotics". Probiotics are living
microorganisms that bring a benefit to the host when administered in sufficient quantity
Here the investigators will study, in normal young male volunteers, the potential to
modulate post-prandial metabolic and inflammatory responses by the administration of a
yoghourt containing the probiotic Lactobacillus rhamnosus (LGG).
This is a prospective, randomized, double-blind and cross-over study designed to evaluate
the potential of a probiotic (Lactobacillus rhamnosus) to modulate the post prandial
metabolic and inflammatory response of normale healthy individuals.
After a wash out period during which volunteers will have to follow a diet devoid of all
milk or milk-derived products, they will receive, in random order, either a daily dose of
the probiotic, or a daily dose of acidified milk (control) for a total of three consecutive
weeks. At the end of each of these period, they will be submitted to a day of investigation,
during which their metabolic and inflammatory profile will be studied following the
ingestion of a standard test meal. The potential for the probiotic to modulate the metabolic
and inflammatory parameters will be evaluated.
The test meal will provide 1004Kcal under the form of 45.4g proteins (17%), 69g total fatty
acids (62%), and 52.6g glucids (21%) as previously published (Schwander et al, J Nut 2014).
Probiotic, Yoghourt, Inflammation, Metabolomics
Centre Hospitalier Universitaire Vaudois
Centre Hospitalier Universitaire Vaudois, Agroscope Liebefeld-Posieux Research Station ALP