SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition

NCT ID: NCT02219295


Title
Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition
Purpose
We investigate the impact of taste receptors (sweet, bitter and umami) on human metabolism. There ist growing evidence, that components of the taste signalling system, including the taste receptor proteins , have important functions in the regulation of metabolic parameters in non-gustatory tissues.
Details
We apply different sweet, bitter and umami taste compounds in a single dose in the human intervention. We use substances as for instance glucose, sucrose,saccharin and lactisol in the sweet part, and substances from cabbage, beer or red endive in the bitter part. For umami we take glutamate. Blood samples are collected at baseline and 6 times thereafter up to 3hours, to analyse the incretins GLP-1(glucagon-like peptide 1) and GIP(gastrointestinal polypeptide) and other peptide hormones as insulin and PYY(peptide tyrosin trosin) in human beings. Gastrointestinal mucosa is taken by gastroscopy from the lower duodenum from study subjects for analysis for the presence or absence of functional taste receptors in gastrointestinal tissues.
Conditions
Disorder of Glucose Regulation
Keywords
SGLT1 (sodium dependent glucose transporter), Glut-transporters, taste receptors genes, sweet taste receptor T1R2T1R3, bitter taste receptors of the hTAS2gene family
Source
German Institute of Human Nutrition
Sponsors
German Institute of Human Nutrition, Technische Universität München
Status
Completed
Acronym
SEGATROM
Last Updated
17 Mar 2015
URL
Official Link
Locations
Germany