Effects of Probiotic Supplementation on Colonic Transit Time and Gastrointestinal Symptoms in Adults With Constipation.
Effects of 4-week Bifidobacterium-lactis HN019 Supplementation on Colonic Transit Time and Gastrointestinal Symptoms in Adults With Functional Constipation: A Double-blind, Randomized, Placebo-controlled Dose-ranging Trial
To determine if Bifidobacterium lactis HN109 improves transit time and gastrointestinal
symptoms in adults with constipation.
Constipation is a commonly diagnosed gastrointestinal disorder with an estimated prevalence
in the general population of 12-19%, which results in lower quality of life and significant
healthcare costs to the individual. Almost 9 in 10 physician visits for constipation result
in a laxative prescription. Additionally, consumers in the USA and in the United Kingdom
spend almost 1 billion dollars annually for over-the-counter laxatives. Chronic constipation
is diagnosed almost solely on patient symptoms, which generally includes unsatisfactory
defecation due to infrequent stools, difficult stool passage, or both. The cause of chronic
constipation is unknown and likely multifactorial with physiological changes, psychological
factors, and lifestyle influences identified as possible culprits. Consequently,
identification of effective constipation treatments remains a challenge.
The initial management of constipation symptoms is focused on evaluating lifestyle and diet
variables as possible culprits. If lifestyle modifications are unsuccessful in alleviating
constipation, various medications may be prescribed. In fact, about 50% of adults with
constipation are not completely satisfied with available treatments. Consequently, there is
a clear need for alternative constipation treatments that are safe, effective, and
Probiotics are live micro-organisms that result in a health benefit for the host when
administered in adequate dosages. In recent years, probiotics have been commonly used to
alleviate symptoms in a variety of gastrointestinal disorders. It is hypothesized that
probiotics help to maintain gut lumen homeostasis by hindering growth of luminal pathogens
and restoring the normal flora of the gut. As such, the use of probiotics for the relief of
constipation symptoms is very promising. Numerous studies have been published addressing the
utility of probiotics for gastrointestinal health including constipation. However, since
probiotic efficacy is largely strain-specific, each specific strain must be individually
tested in clinical trials.
Given the promising clinical results of probiotics on gastrointestinal health to date, the
objective of this clinical trial is to evaluate the safety and effectiveness of 4-week
Bifidobacterium lactis HN019 supplementation, in a dose-ranging fashion, on Colonic Transit
Time (CTT) and gastrointestinal symptoms in adults with constipation.
Constipation, Gastrointestinal Disorder
Gastrointestinal disorder, Constipation, Probiotics, Dietary supplement
Danisco Sweeteners Oy
Danisco Sweeteners Oy, Eurofins Optimed