Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabis

NCT ID: NCT02165176


Title
Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabis
Purpose
Few studies have been conducted to assess the pharmacokinetic and pharmacodynamic effects of orally consumed intact cannabis (e.g., cannabis-containing brownies). Careful analysis of oral cannabis dose effects on these parameters is required to determine the level and duration of biological cannabinoid exposure and associated subjective, cardiovascular and cognitive effects. The present study will evaluate the detection of cannabinoids in oral fluid, plasma, hair, and urine for up to 9 days following consumption of oral cannabis (10mg, 25mg, or 50mg THC). In addition, we will conduct subjective, behavioral, and cognitive performance assessments to evaluate the time course of the consequences of oral cannabis ingestion among study participants. The outcomes of the study will extend scientific knowledge about the behavioral pharmacology and toxicology of oral cannabis and can inform policies regarding clinical, workplace and roadside drug testing programs.
Details
Conditions
Cannabis
Keywords
cannabis, toxicology, intoxication
Source
Johns Hopkins University
Sponsors
Johns Hopkins University, Substance Abuse and Mental Health Services Administration (SAMHSA), RTI International
Status
Completed
Acronym
Last Updated
19 Oct 2015
URL
Official Link
Locations
United States