Colistin Pharmacokinetics in Continuous Renal Replacement Therapy

NCT ID: NCT02081560


Title
Colistimethate and Colistin Pharmacokinetics in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT)
Purpose
The blood concentration of the antibiotic colistin is determined in patients in whom kidney function is reduced such that a renal replacement therapy is needed. Hypothesis:no dose reduction is needed in patients undergoing continuous renal replacement therapy over 24h because colistin is sufficiently removed by this procedure.
Details
After administration of intravenous Colistin multiple blood samples are drawn over one dosing interval on day 1, 3, and 5 of treatment. Patients are monitored for signs of neuro- and nephrotoxicity
Conditions
Infection
Keywords
pharmacokinetics, antibiotic, Gram negative, continuous renal replacement therapy
Source
University of Zurich
Sponsors
University of Zurich
Status
Unknown status
Acronym
Last Updated
05 Mar 2014
URL
Official Link
Locations
Switzerland