Role of the Catechol-O-methyltransferase (COMT) in the Physiological Regulation of Vigilance

NCT ID: NCT02080715


Title
A Randomized, Double-blind, Placebo-controlled Examination of the Effects of Tolcapone (TASMAR) on Vigilance in Healthy Volunteers After Sleep Deprivation
Purpose
In this study, pharmacologic effects of COMT inhibition during sleep deprivation in healthy subjects in dependence of their Val158Met genotype of COMT are studied. Potential effects are identified by measurement of vigilance and cognitive performance as well as EEG measurements during wake and sleep. - Trial with medicinal product
Details
Conditions
Healthy
Keywords
Sleep-wake, regulation, volunteers
Source
University of Zurich
Sponsors
University of Zurich
Status
Completed
Acronym
Last Updated
10 Sep 2014
URL
Official Link
Locations
Switzerland