Essential Fatty Acid Status & Immune Function in Parenteral Nutrition Patients

NCT ID: NCT01986153


Title
Essential Fatty Acid Status & Immune Function in Parenteral Nutrition Patients
Purpose
The purpose of this study is to determine if patients on long-term olive oil-based parenteral nutrition have an adequate essential fatty acid status and immune status, compared to age- and sex-matched healthy controls.
Details
Patients, who suffer from severe chronic intestinal failure and whose nutritional intake cannot be met by oral food intake, have as their final option total parenteral nutrition, which contains all necessary macro- and micronutrients. Lipid emulsions are essential for these patients as they are a source of non glucose fuel calories, and they contain (essential) fatty acids which are important as structural component for many cells in the human body. Home parenteral nutrition patients are at risk for essential fatty acid deficiency. Data are lacking that indicate the optimal amount of essential fatty acids required for these patients. The latter seems especially relevant for patients receiving lipid prescriptions which are low in essential fatty acids, like ClinOleic®. Long-term parenteral nutrition dependent patients successfully use ClinOleic®. It is however unknown whether these patient remain to have an adequate essential fatty acid status in the long run.
Conditions
Intestinal Failure
Keywords
Fatty acid, essential, Immune system, Home parenteral nutrition
Source
Radboud University
Sponsors
Geert Wanten, Baxter Healthcare Corporation
Status
Completed
Acronym
Last Updated
10 Nov 2014
URL
Official Link
Locations
Netherlands