Nutrition Blood Outcomes Following Tocotrienol N2B
Human Blood Outcomes Following Tocotrienol Supplementation - Nutrition Phase IIB NUTRITION PHASE IIB
A natural form of vitamin E called tocotrienol (TCT) has blood thinning and cholesterol
lowering properties, both of which may benefit stroke survivors. This study is being
conducted to determine the blood thinning and cholesterol lowering properties of TCT in
stroke or TIA (transient ischemic attack, which is also referred to as a "mini-stroke")
survivors that are receiving the standard treatment for prevention of recurrent stroke.
Study Hypothesis: Oral TCT decreases the incidence of aspirin and clopidogrel nonresponders,
increases the extent of inhibition of platelet aggregation, and decreases LDL without
significant side effects in stroke patients.
In this Phase IIB trial the goal is to determine the effects of orally supplemented TCT on
platelet function and cholesterol as well as the safety in patients with TIA (transient
ischemic attack) or stroke in addition to the standard treatment for stroke prevention.
Recurrent cardiovascular events including stroke, TIA, heart attack, venous thrombosis,
pulmonary embolism, systemic embolism will also be recorded. In patients with recurrent
stroke, severity of the stroke and stroke size measured from MR (magnetic resonance) or CT
(computed tomography) imaging will also be collected. We expect that TCT will inhibit blood
clotting and lower cholesterol more than current standard treatment without significantly
increasing bleeding risks or other side effects. Future work is planned in a larger
TIA/stroke population to examine whether TCT adds to standard medical care in terms of
decreasing incidence of stroke and improving outcomes following stroke.
Stroke survivors, TIA survivors, Vitamin E, Carotech, Tocotrienol
Ohio State University
Ohio State University, Malaysia Palm Oil Board
Active, not recruiting