The Impact of the French PNNS Guidelines on Vascular Function Following a Standardised Breakfast.

NCT ID: NCT01579409


Title
The Impact of the French National Program for Nutrition and Health Guidelines on Vascular Function Following a Standardised Breakfast:The Nutri-Vasc Study
Purpose
In France, primary cardiovascular and metabolic prevention is supported by the French National Program for Nutrition and Health (PNNS: Programme National Nutrition Santé). The investigators made the hypothesis that, independently of other diseases, the non adherence in PNNS guidelines would lead to arterial stiffness, endothelial dysfunction, change in microcirculation and in cardiac autonomic system. These changes may exist at fasting but also be reinforced after a standardised breakfast. The investigators aim is to evaluate arterial stiffness, endothelial function, microcirculation and cardiac autonomic system according to PNNS status in a case control study.
Details
This is a case / control pilot nested in SU.VI.MAX 2 (SUpplémentation en VItamines et Minéraux Anti-oXydants) study. The randomized longitudinal placebo controlled SU.VI.MAX study tested the preventive effect of vitamin and antioxidant minerals supplementation on the incidence and the mortality from cardiovascular pathologies and cancers. SU.VI.MAX 2 was the extension of the previous study and included 7200 subjects for whom food habits were known and characterized according to PNNS guidelines (PNNS score). The subjects will be pre-selected from the original cohort SU.VI.MAX2 if they have a PNNS score in 2007 in the 1-40th or 60-100th percentiles of distribution. If they accept to participate, a new PNNS score will be calculated in 2012-2013 and the subjects in the 1-25th or 75-100th percentiles will be included and explored during one day of participation. Our aim is to evaluate arterial stiffness, endothelial function, microcirculation and cardiac autonomic system according to PNNS status in a case control study. Our secondary objective is to evaluate the same parameters in the same subjects but after a breakfast containing 75 g glucose.
Conditions
French PNNS Guidelines in Vascular Function
Keywords
Nutrition, Arterial stiffness, Endothelial dysfunction, Microcirculation, Cardiac autonomic system.
Source
Institut National de la Santé Et de la Recherche Médicale, France
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Status
Unknown status
Acronym
NUTRIVASC
Last Updated
15 Apr 2012
URL
Official Link
Locations