Compassionate Use of IV Fish Oil for Parenteral Nutrition (PN) Liver Injury

NCT ID: NCT01425567


Title
Compassionate Use of an Intravenous Lipid Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Children
Purpose
If a child is unable to tolerate enough of his/her feeding orally to grow and requires that nutrition is given by vein (IV parenteral nutrition), it can result in severe liver disease. This is called cholestasis. IV fat that children receive may be contributing to this liver disease. A different fat mixture comprised from fish oil could be used in place of intralipid. This is a compassionate use of the fish oil and not a comparison of the two. We believe the use of fish oil may provide less liver disease and decrease the need of liver transplant or dying than those who receive the usual fat.
Details
If a child is unable to tolerate enough of his/her feeding orally to grow and requires that nutrition is given by vein (IV parenteral nutrition), it can result in severe liver disease. This is called cholestasis. IV fat that children receive may be contributing to this liver disease. A different fat mixture comprised from fish oil could be used in place of intralipid. This is a compassionate use of the fish oil and not a comparison of the two. We believe the use of fish oil may improve liver disease and decrease the need of liver transplant or dying than those who receive the usual fat. The rest of the IV nutrition is as per standard of care
Conditions
Liver Disease
Keywords
cholestasis, parenteral nutrition
Source
The University of Texas Health Science Center at San Antonio
Sponsors
The University of Texas Health Science Center at San Antonio
Status
Recruiting
Acronym
Omegaven
Last Updated
08 Jan 2017
URL
Official Link
Locations
United States