Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes

NCT ID: NCT01390480


Title
Placebo Controlled Pilot Study on Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes on Immunological, Endocrine and Metabolic Parameters: Step 2 in the Austrian Diabetes Prevention Programme
Purpose
In this placebo controlled study the investigators aim to investigate the effects of vitamin D supplementation in subjects with new onset of type 1 diabetes on immunological, endocrine and metabolic parameters.
Details
This is a bicentric, randomized placebo controlled, double blind study, with the aim to evaluate the effect of vitamin D supplementation in subjects with new onset of type 1 diabetes on immunological, endocrine and metabolic parameters. The primary study goal is to evaluate the influence of vitamin D supplementation on the number and function of the master regulatory T-cells under controlled conditions within 13 months. The secondary study goals are a comprehensive immune phenotyping to determine whether Vit D produces changes consistent with a general improvement in immune homeostasis that supports ß-cell tolerating interventions, the assessment of ß-cell function in all subjects to obtain preliminary data on the effects of Vit D on ß-cell survival.
Conditions
Type 1 Diabetes
Keywords
vitamin D, Autoimmune disease, diabetes
Source
Medical University of Graz
Sponsors
Medical University of Graz, Medical University of Vienna
Status
Completed
Acronym
Last Updated
15 Apr 2015
URL
Official Link
Locations
Austria