The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly

NCT ID: NCT00843479


Title
The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly.
Purpose
Like most endocrine axes, the entero-insular axis is expected to go through an age-related physiological deterioration, what might contribute to special features of the elderly onset type 2 diabetes in comparison to middle-age. Twenty four NGT volunteers will be evaluated by a meal tolerance test (MTT) for incretin hormone measurements, and by the hyperglycemic clamp followed by an arginine test for assessing the beta-cell function and the acute insulin response. Others parameters as body composition and basic biochemistry will be also evaluated at Laboratory of Investigation on Metabolism and Diabetes - LIMED / State university of Campinas, Brazil. The characterization of the glucagon-like peptide-1 (GLP-1) production, dipeptidyl peptidase IV (DPP-IV) activity and/or endocrine pancreas incretin-response at aging, might be an interesting evidence to reinforce an incretin-based therapeutic approach for elderly onset type 2 diabetes.
Details
Conditions
Diabetes Mellitus, Type 2, Insulin Resistance
Keywords
diabetes mellitus, type 2, Insulin resistance, Aging, Incretins, DPP-IV protein, human, Glucagon-Like Peptide 1, Gastric Inhibitory Polypeptide, insulin, glucagon, ghrelin
Source
University of Campinas, Brazil
Sponsors
University of Campinas, Brazil
Status
Completed
Acronym
Last Updated
06 Mar 2013
URL
Official Link
Locations
Brazil