Nutrition, Immunology and Epidemiology of Tuberculosis

NCT ID: NCT00197704


Title
Nutrition, Immunology and Epidemiology of Tuberculosis
Purpose
The purpose of this study is to determine the efficacy of micronutrient supplementation among patients with active tuberculosis, half of who are co-infected with HIV-1
Details
Tuberculosis (TB) remains the single most common infectious disease cause of mortality. We propose to examine the inter- relationships of nutrition, immunology, and epidemiology with respect to TB in Tanzania. Given that TB is so much linked with HIV immunologically, clinically, and epidemiologically, it is essential to examine how these relationships are modified by HIV infection. Published animal and human studies suggest that vitamin deficiency is associated with poor immune response in TB. By modulating immune function, nutritional supplements may be a useful adjunct to anti-TB drugs, and could lead to the development of shorter drug regimens. All patients will receive standard anti-TB therapy. Follow-up visits will occur every two weeks for the first 2 months and monthly thereafter till the end of the study.
Conditions
Tuberculosis
Keywords
Tuberculosis, HIV, Tanzania, multivitamins
Source
Harvard School of Public Health
Sponsors
Harvard School of Public Health, Muhimbili University of Health and Allied Sciences
Status
Completed
Acronym
Last Updated
08 Nov 2010
URL
Official Link
Citations/Publications
Villamor E, Mugusi F, Urassa W, Bosch RJ, Saathoff E, Matsumoto K, Meydani SN, Fawzi WW. A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. J Infect Dis. 2008 Jun 1;197(11):1499-505. doi: 10.1086/587846.

Locations
United States